Evidence for the involvement of TNF-α and IL-1β in the antinociceptive and anti-inflammatory activity of Stachys lavandulifolia Vahl. (Lamiaceae) essential oil and (-)-α-bisabolol, its main compound, in mice

• Published in: Journal of ethnopharmacology Vol. 191; pp. 9 - 18
• Main Authors: Barreto, Rosana S.S., Quintans, Jullyana S.S., Amarante, Ruthy K.L., Nascimento, Tainá S., Amarante, Rosana S., Barreto, André S., Pereira, Erik W.M., Duarte, Marcelo C., Coutinho, Henrique D.M., Menezes, Irwin R.A., Zengin, Gokhan, Aktumsek, Abdurrahman, Quintans-Júnior, Lucindo J.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 15.09.2016
• Subjects: (-)-α-bisabolol; analgesic effect; Analgesics - isolation & purification; Analgesics - pharmacology; Animals; Anti-Infective Agents - isolation & purification; Anti-Infective Agents - pharmacology; anti-inflammatory activity; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; essential oils; Facial pain; Facial Pain - chemically induced; Facial Pain - physiopathology; Facial Pain - prevention & control; Flame Ionization; Formaldehyde; formalin test; Gas Chromatography-Mass Spectrometry; Glutamic Acid; inflammation; interleukin-1beta; Interleukin-1beta - metabolism; Male; males; medicinal plants; Mice; morphine; Nociception - drug effects; Nociceptive Pain - chemically induced; Nociceptive Pain - physiopathology; Nociceptive Pain - prevention & control; Oils, volatile; Oils, Volatile - isolation & purification; Oils, Volatile - pharmacology; physical activity; Phytotherapy; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Oils - isolation & purification; Plant Oils - pharmacology; Plants, Medicinal; pleurisy; Pleurisy - chemically induced; Pleurisy - metabolism; Pleurisy - prevention & control; polysorbates; Sesquiterpenes - isolation & purification; Sesquiterpenes - pharmacology; Sesquiterpenes, citokynes; spathulenol; Stachys - chemistry; Stachys lavandulifolia; Time Factors; traditional medicine; tumor necrosis factor-alpha; Tumor Necrosis Factor-alpha - metabolism; Turkey (country); Turkey (country); Oils, volatile; Facial pain; Sesquiterpenes, citokynes; Stachys lavandulifolia; (-)-α-bisabolol

Stachys lavandulifolia Vahl (Lamiaceae) is a medicinal plant widely used in Turkey and Iranian folk medicine due to its analgesic and anti-inflammatory properties, but little is known about its essential oil. We studied the antinociceptive and anti-inflammatory effects of S. lavandulifolia essential...