Evidence for the involvement of TNF-α and IL-1β in the antinociceptive and anti-inflammatory activity of Stachys lavandulifolia Vahl. (Lamiaceae) essential oil and (-)-α-bisabolol, its main compound, in mice - Barreto, Rosana S.S.; Quintans, Jullyana S.S.; Amarante, Ruthy K.L.; Nascimento, Tainá S.; Amarante, Rosana S.; Barreto, André S.; Pereira, Erik W.M.; Duarte, Marcelo C.; Coutinho, Henrique D.M.; Menezes, Irwin R.A.; Zengin, Gokhan; Aktumsek, Abdurrahman; et al. (Journal of ethnopharmacology, 2016)
Keywords: (-)-α-bisabolol; analgesic effect; Analgesics - isolation & purification; Analgesics - pharmacology; Animals; Anti-Infective Agents - isolation & purification; Anti-Infective Agents - pharmacology; anti-inflammatory activity; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; essential oils; Facial pain; Facial Pain - chemically induced; Facial Pain - physiopathology; Facial Pain - prevention & control; Flame Ionization; Formaldehyde; formalin test; Gas Chromatography-Mass Spectrometry; Glutamic Acid; inflammation; interleukin-1beta; Interleukin-1beta - metabolism; Male; males; medicinal plants; Mice; morphine; Nociception - drug effects; Nociceptive Pain - chemically induced; Nociceptive Pain - physiopathology; Nociceptive Pain - prevention & control; Oils, volatile; Oils, Volatile - isolation & purification; Oils, Volatile - pharmacology; physical activity; Phytotherapy; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Oils - isolation & purification; Plant Oils - pharmacology; Plants, Medicinal; pleurisy; Pleurisy - chemically induced; Pleurisy - metabolism; Pleurisy - prevention & control; polysorbates; Sesquiterpenes - isolation & purification; Sesquiterpenes - pharmacology; Sesquiterpenes, citokynes; spathulenol; Stachys - chemistry; Stachys lavandulifolia; Time Factors; traditional medicine; tumor necrosis factor-alpha; Tumor Necrosis Factor-alpha - metabolism; Turkey (country); Turkey (country); Oils, volatile; Facial pain; Sesquiterpenes, citokynes; Stachys lavandulifolia; (-)-α-bisabolol