Enhanced esterification process of 5-hydroxyeicosatetraenoic acid (5-HETE) in PMN from asthmatic patients

• Published in: Prostaglandins Vol. 43; no. 6; pp. 583 - 594
• Main Authors: Radeau, T., Godard, P., Chavis, C., Crastes de Paulet, A., Damon, M.
• Format: Journal Article
• Language: English
• Published: Stoneham, MA Elsevier Inc 01.06.1992; Butterworth-Heinemann
• Subjects: 5-HETE; Adult; Asthma; Asthma - blood; Biological and medical sciences; Calcimycin - pharmacology; Cell Migration Inhibition; Chromatography, High Pressure Liquid; Chronic obstructive pulmonary disease, asthma; Esterification; Humans; Hydroxyeicosatetraenoic Acids - metabolism; Medical sciences; Middle Aged; Neutrophils - drug effects; Neutrophils - metabolism; Platelet Activating Factor - pharmacology; PMN activation; Pneumology; Reference Values; PMN activation; 5-HETE; Asthma; Human; Cell motility; Pathophysiology; Respiratory disease; Arachidonic acid derivatives; Obstructive pulmonary disease; Neutrophil; Esterification; Platelet activating factor; HETE

Polymorphonuclear neutrophils (PMN) generate 5-HETE which can be retained within cells as free metabolites or esterified into cellular lipids. Since this metabolite has been shown to have certain inflammatory porperties, we compared the generation and distribution profile of 5-HETE in A 23187-stimul...