Empaglifozin mitigates NAFLD in high-fat-fed mice by alleviating insulin resistance, lipogenesis and ER stress

• Published in: Molecular and cellular endocrinology Vol. 498; p. 110539
• Main Authors: Petito-da-Silva, Tamiris Ingrid, Souza-Mello, Vanessa, Barbosa-da-Silva, Sandra
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.12.2019
• Subjects: beta oxidation; calorimetry; Empagliflozin; endoplasmic reticulum; Endoplasmic reticulum stress; energy expenditure; fatty liver; genes; glucose tolerance; glucose tolerance tests; Hepatic steatosis; high fat diet; homeostasis; insulin resistance; lipid content; lipids; Lipogenesis; liver; mice; peroxisome proliferator-activated receptor alpha; peroxisome proliferator-activated receptor gamma; pleiotropy; protein synthesis; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; Western blotting; Empagliflozin; Hepatic steatosis; Lipogenesis; Endoplasmic reticulum stress

To evaluate the pleiotropic effects of empagliflozin in the liver through lipogenesis, beta-oxidation, and endoplasmic reticulum stress pathways. Male C57Bl/6 mice, 3 months of age, received a control diet (C, 10% lipids, n = 20) or high-fat diet (HF, 50% lipids, n = 20) for 10 weeks, after that, th...