High-Density Substrate Mapping in Brugada Syndrome Combined Role of Conduction and Repolarization Heterogeneities in Arrhythmogenesis

• Published in: Circulation (New York, N.Y.) Vol. 120; no. 2; pp. 106 - 117
• Main Authors: Lambiase, P.D., Ahmed, A.K., Ciaccio, E.J., Brugada, R., Lizotte, E., Chaubey, S., Ben-Simon, Ron, Chow, A.W., Lowe, M.D., McKenna, W.J.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 14.07.2009
• Subjects: Action Potentials - physiology; Adult; Aged; Arrhythmias, Cardiac - physiopathology; Biological and medical sciences; Blood and lymphatic vessels; Brugada Syndrome - genetics; Brugada Syndrome - physiopathology; Cardiology. Vascular system; Case-Control Studies; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Electrocardiography; Electrophysiologic Techniques, Cardiac; Endocardium - physiopathology; Female; Genetic Testing; Heart Conduction System - physiopathology; Humans; Injuries of the limb. Injuries of the spine; Male; Medical sciences; Middle Aged; Muscle Proteins - genetics; Mutation - genetics; NAV1.5 Voltage-Gated Sodium Channel; Sodium Channels - genetics; Tachycardia, Ventricular - physiopathology; Traumas. Diseases due to physical agents; Cartography; Conduction; Heterogeneity; Repolarization; mapping; Arrhythmia; Brugada syndrome; Heart disease; Cardiovascular disease

Background— Two principal mechanisms are thought to be responsible for Brugada syndrome (BS): (1) right ventricular (RV) conduction delay and (2) RV subepicardial action potential shortening. This in vivo high-density mapping study evaluated the conduction and repolarization properties of the RV in...