Grouper (Epinephelus coioides) MyD88 and Tollip: Intracellular localization and signal transduction function

• Published in: Fish & shellfish immunology Vol. 42; no. 1; pp. 153 - 158
• Main Authors: Li, Yan-Wei, Wang, Zheng, Mo, Ze-Quan, Li, Xia, Luo, Xiao-Chun, Dan, Xue-Ming, Li, An-Xing
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2015
• Subjects: Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Cluster Analysis; Cytoplasm - metabolism; DNA Primers - genetics; DNA, Complementary - genetics; Epinephelus coioides; HEK293 Cells; Humans; Intracellular localization; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Luciferase reporter assay; Luciferases; Marine; Molecular Sequence Data; MyD88; Myeloid Differentiation Factor 88 - genetics; Myeloid Differentiation Factor 88 - metabolism; NF-kappa B - metabolism; Open Reading Frames; Perciformes - metabolism; Perciformes - physiology; Phylogeny; Sequence Analysis, DNA; Signal Transduction - physiology; Tollip; Epinephelus coioides; Luciferase reporter assay; Intracellular localization; MyD88; Tollip

Myeloid differentiation factor 88 (MyD88) and Toll-interacting protein (Tollip) are two important regulatory proteins of the Toll-like receptor (TLR) signaling pathways. In this paper, a Tollip sequence of grouper (Epinephelus coioides) was identified and the signal transduction functions of Tollip...