Gold nanoparticles produce transient reactive gliosis in the adult brain
[Display omitted] •Gold nanoparticles (GNPs) produces a mild glial reactivity.•Intracerebral injection of GNPs induces a transient astrocytic response.•Microglial cells rapidly respond to GNPs, but this response declines in 14 days.•Glial response against GNPs is self-limited and mainly confined to...
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| Published in | Neuroscience research Vol. 170; pp. 76 - 86 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Ireland
Elsevier B.V
01.09.2021
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| Subjects | |
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| Abstract | [Display omitted]
•Gold nanoparticles (GNPs) produces a mild glial reactivity.•Intracerebral injection of GNPs induces a transient astrocytic response.•Microglial cells rapidly respond to GNPs, but this response declines in 14 days.•Glial response against GNPs is self-limited and mainly confined to the perilesional area.•GNPs may be good carriers to deliver long-lasting drugs into the brain.
Gold nanoparticles (GNPs) have unique physical and chemical properties that allow them to function as a drug-delivery system for several tissues: skin, eye, liver, and others. However, information about the biological response of brain tissue against GNPs is limited. Astrocytes and microglia cells are the first line of defense against brain insults and proper indicators of the level of brain damage. This study was aimed to evaluate the astrocytic and microglia response after an intracerebral injection of polyethylene-glycol-coupled GNPs (PEGylated GNPs). We injected spherical PEGylated GNPs (85 × 106 nanoparticles /nl) with a glass micropipette (inner diameter =35 μm) into the striatum of P60 CD1 mice. We evaluated the cellular response of astrocytes and microglia on days 3, 7, 14, 30, and 90 after intracerebral injection. For both astrocytes and microglia cells, our findings indicated that the glial response was transient and mainly circumscribed to the injection site. This evidence suggests that PEGylated GNPs are well-tolerated by the neural tissue. Understanding the effects of GNPs in the adult brain is a crucial step to design proper pharmacological vehicles to deliver long-lasting drugs. |
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| AbstractList | Gold nanoparticles (GNPs) have unique physical and chemical properties that allow them to function as a drug-delivery system for several tissues: skin, eye, liver, and others. However, information about the biological response of brain tissue against GNPs is limited. Astrocytes and microglia cells are the first line of defense against brain insults and proper indicators of the level of brain damage. This study was aimed to evaluate the astrocytic and microglia response after an intracerebral injection of polyethylene-glycol-coupled GNPs (PEGylated GNPs). We injected spherical PEGylated GNPs (85 × 10
nanoparticles /nl) with a glass micropipette (inner diameter =35 μm) into the striatum of P60 CD1 mice. We evaluated the cellular response of astrocytes and microglia on days 3, 7, 14, 30, and 90 after intracerebral injection. For both astrocytes and microglia cells, our findings indicated that the glial response was transient and mainly circumscribed to the injection site. This evidence suggests that PEGylated GNPs are well-tolerated by the neural tissue. Understanding the effects of GNPs in the adult brain is a crucial step to design proper pharmacological vehicles to deliver long-lasting drugs. [Display omitted] •Gold nanoparticles (GNPs) produces a mild glial reactivity.•Intracerebral injection of GNPs induces a transient astrocytic response.•Microglial cells rapidly respond to GNPs, but this response declines in 14 days.•Glial response against GNPs is self-limited and mainly confined to the perilesional area.•GNPs may be good carriers to deliver long-lasting drugs into the brain. Gold nanoparticles (GNPs) have unique physical and chemical properties that allow them to function as a drug-delivery system for several tissues: skin, eye, liver, and others. However, information about the biological response of brain tissue against GNPs is limited. Astrocytes and microglia cells are the first line of defense against brain insults and proper indicators of the level of brain damage. This study was aimed to evaluate the astrocytic and microglia response after an intracerebral injection of polyethylene-glycol-coupled GNPs (PEGylated GNPs). We injected spherical PEGylated GNPs (85 × 106 nanoparticles /nl) with a glass micropipette (inner diameter =35 μm) into the striatum of P60 CD1 mice. We evaluated the cellular response of astrocytes and microglia on days 3, 7, 14, 30, and 90 after intracerebral injection. For both astrocytes and microglia cells, our findings indicated that the glial response was transient and mainly circumscribed to the injection site. This evidence suggests that PEGylated GNPs are well-tolerated by the neural tissue. Understanding the effects of GNPs in the adult brain is a crucial step to design proper pharmacological vehicles to deliver long-lasting drugs. |
| Author | Gonzalez-Perez, Oscar Gonzalez-Pedroza, Maria G. Lira-Diaz, Eduardo Morales-Luckie, Raul A. Vasquez, Clemente |
| Author_xml | – sequence: 1 givenname: Eduardo surname: Lira-Diaz fullname: Lira-Diaz, Eduardo organization: Laboratory of Neuroscience, School of Psychology, University of Colima, Colima, 28040, Mexico – sequence: 2 givenname: Maria G. surname: Gonzalez-Pedroza fullname: Gonzalez-Pedroza, Maria G. organization: Department of Nanomaterials, Sustainable Chemistry Research Center, National Autonomous University of Mexico/Autonomous University of the State of Mexico, Toluca, 50200, Mexico – sequence: 3 givenname: Clemente surname: Vasquez fullname: Vasquez, Clemente organization: University Center for Biomedical Research, University of Colima, Colima, 28040, Mexico – sequence: 4 givenname: Raul A. surname: Morales-Luckie fullname: Morales-Luckie, Raul A. organization: Department of Nanomaterials, Sustainable Chemistry Research Center, National Autonomous University of Mexico/Autonomous University of the State of Mexico, Toluca, 50200, Mexico – sequence: 5 givenname: Oscar surname: Gonzalez-Perez fullname: Gonzalez-Perez, Oscar email: osglez@ucol.mx organization: Laboratory of Neuroscience, School of Psychology, University of Colima, Colima, 28040, Mexico |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33358926$$D View this record in MEDLINE/PubMed |
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•Gold nanoparticles (GNPs) produces a mild glial reactivity.•Intracerebral injection of GNPs induces a transient astrocytic... Gold nanoparticles (GNPs) have unique physical and chemical properties that allow them to function as a drug-delivery system for several tissues: skin, eye,... |
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| Title | Gold nanoparticles produce transient reactive gliosis in the adult brain |
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