Superparamagnetically labelled neutrophils as potential abscess-specific contrast agent for MRI

In order to evaluate the potential of superparamagnetically labelled neutrophils as inflammation-specific contrast agents for magnetic resonance imaging (MRI), various types of magnetite particles were associated with isolated human neutrophils in vitro and subsequent effects on characteristic cellu...

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Published inMagnetic resonance imaging Vol. 13; no. 3; pp. 393 - 400
Main Authors Krieg, Felix M., Andres, Roger Y., Winterhalter, Kaspar H.
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 1995
Elsevier Science
Subjects
Abscess - diagnosis
Animals
Biological and medical sciences
Cell Aggregation - drug effects
Chemotaxis, Leukocyte - drug effects
Contrast agents
Contrast Media
Contrast-enhanced MRI
Ferrosoferric Oxide
Humans
In Vitro Techniques
Investigative techniques, diagnostic techniques (general aspects)
Iron - pharmacology
Magnetic Resonance Imaging
Magnetite
Medical sciences
Miscellaneous. Technology
Models, Structural
Neutrophils - physiology
Oxides - pharmacology
Rabbits
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Superoxides - metabolism
Superparamagnetic iron oxide particles
Superparamagnetically labelled neutrophils
Superparamagnetic iron oxide particles
Contrast agents
Superparamagnetically labelled neutrophils
Magnetite
Contrast-enhanced MRI
Image quality
Abscess
Paramagnetic contrast agent
Neutrophil
Nuclear magnetic resonance imaging
Optimization
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Abstract In order to evaluate the potential of superparamagnetically labelled neutrophils as inflammation-specific contrast agents for magnetic resonance imaging (MRI), various types of magnetite particles were associated with isolated human neutrophils in vitro and subsequent effects on characteristic cellular functions investigated. Exposure to uncoated magnetite caused strong irreversible cell aggregation, whereas uptake of polystyrene-embedded magnetite microcrystals (Estapor ® M 1- 0.70 60 ) occurred with only minor changes in neutrophil adhesion properties, cellular metabolism, and chemotactic behaviour in vitro. As revealed by MR phantom imaging, Estapor ®-labelled neutrophils generated visible contrast above a threshold concentration of 1–2 μg Fe/g in a tissue-equivalent environment. Intravenous administration of labelled neutrophils to rabbits resulted in local magnetite accumulation up to 2.4 μg Fe/g tissue in artificial inflammation sites. Subsequent T 2-weighted imaging of an intramuscular abscess clearly demonstrated the expected hypointense area surrounding the typically bright core of inflammation.
AbstractList In order to evaluate the potential of superparamagnetically labelled neutrophils as inflammation-specific contrast agents for magnetic resonance imaging (MRI), various types of magnetite particles were associated with isolated human neutrophils in vitro and subsequent effects on characteristic cellular functions investigated. Exposure to uncoated magnetite caused strong irreversible cell aggregation, whereas uptake of polystyrene-embedded magnetite microcrystals (Estapor ® M 1- 0.70 60 ) occurred with only minor changes in neutrophil adhesion properties, cellular metabolism, and chemotactic behaviour in vitro. As revealed by MR phantom imaging, Estapor ®-labelled neutrophils generated visible contrast above a threshold concentration of 1–2 μg Fe/g in a tissue-equivalent environment. Intravenous administration of labelled neutrophils to rabbits resulted in local magnetite accumulation up to 2.4 μg Fe/g tissue in artificial inflammation sites. Subsequent T 2-weighted imaging of an intramuscular abscess clearly demonstrated the expected hypointense area surrounding the typically bright core of inflammation.
In order to evaluate the potential of superparamagnetically labelled neutrophils as inflammation-specific contrast agents for magnetic resonance imaging (MRI), various types of magnetite particles were associated with isolated human neutrophils in vitro and subsequent effects on characteristic cellular functions investigated. Exposure to uncoated magnetite caused strong irreversible cell aggregation, whereas uptake of polystyrene-embedded magnetite microcrystals (Estapor M1-0.70/60) occurred with only minor changes in neutrophil adhesion properties, cellular metabolism, and chemotactic behaviour in vitro. As revealed by MR phantom imaging, Estapor-labelled neutrophils generated visible contrast above a threshold concentration of 1-2 micrograms Fe/g in a tissue-equivalent environment. Intravenous administration of labelled neutrophils to rabbits resulted in local magnetite accumulation up to 2.4 micrograms Fe/g tissue in artificial inflammation sites. Subsequent T2-weighted imaging of an intramuscular abscess clearly demonstrated the expected hypointense area surrounding the typically bright core of inflammation.
Author Andres, Roger Y.
Winterhalter, Kaspar H.
Krieg, Felix M.
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Issue 3
Keywords Superparamagnetic iron oxide particles
Contrast agents
Superparamagnetically labelled neutrophils
Magnetite
Contrast-enhanced MRI
Image quality
Abscess
Paramagnetic contrast agent
Neutrophil
Nuclear magnetic resonance imaging
Optimization
Language English
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Elsevier Science
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Snippet In order to evaluate the potential of superparamagnetically labelled neutrophils as inflammation-specific contrast agents for magnetic resonance imaging (MRI),...
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SubjectTerms Abscess - diagnosis
Animals
Biological and medical sciences
Cell Aggregation - drug effects
Chemotaxis, Leukocyte - drug effects
Contrast agents
Contrast Media
Contrast-enhanced MRI
Ferrosoferric Oxide
Humans
In Vitro Techniques
Investigative techniques, diagnostic techniques (general aspects)
Iron - pharmacology
Magnetic Resonance Imaging
Magnetite
Medical sciences
Miscellaneous. Technology
Models, Structural
Neutrophils - physiology
Oxides - pharmacology
Rabbits
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Superoxides - metabolism
Superparamagnetic iron oxide particles
Superparamagnetically labelled neutrophils
Title Superparamagnetically labelled neutrophils as potential abscess-specific contrast agent for MRI
URI https://dx.doi.org/10.1016/0730-725X(94)00111-F
https://www.ncbi.nlm.nih.gov/pubmed/7791549
https://search.proquest.com/docview/77344322
Volume 13
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