The abasic site lesions in the human telomeric sequence d[TA(G3T2A)3G3]: A thermodynamic point of view

• Published in: Biochimica et biophysica acta Vol. 1820; no. 12; pp. 2037 - 2043
• Main Authors: Virgilio, Antonella, Petraccone, Luigi, Esposito, Veronica, Citarella, Giuseppe, Giancola, Concetta, Galeone, Aldo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2012
• Subjects: Abasic site; calorimetry; Calorimetry, Differential Scanning; Circular Dichroism; Differential scanning calorimetry (DSC); DNA; electrophoresis; G-Quadruplexes; guanine; Guanine - chemistry; guanosine; Humans; oligodeoxyribonucleotides; Oligodeoxyribonucleotides - chemistry; Quadruplex structure; site; telomerase; Telomere; Telomere - chemistry; telomeres; Thermal difference spectrum (TDS); thermal stability; Thermodynamics; Abasic site; Thermal difference spectrum (TDS); Quadruplex structure; Differential scanning calorimetry (DSC); Telomere

The abasic sites represent one of the most frequent lesions of DNA and most of the events able to generate such modifications involve guanine bases. G-rich sequences are able to form quadruplex structures that have been proved to be involved in several important biological processes. In this paper,...