Particle volume changes associated with light transmittance changes in the platelet aggregometer: Dependence upon aggregating agent and effectiveness of stimulus
The increase in light transmittance of aspirin-treated platelet-rich plasma caused by addition of non-saturating doses of ADP and, at earlier times, of adrenaline is correlated with formation of aggregates having a volume in the range 490-8580 fl. and containing 100-2000 platelets. The disappearance...
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| Published in | Thrombosis research Vol. 41; no. 5; pp. 615 - 626 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Elsevier Ltd
01.03.1986
Elsevier Science |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The increase in light transmittance of aspirin-treated platelet-rich plasma caused by addition of non-saturating doses of ADP and, at earlier times, of adrenaline is correlated with formation of aggregates having a volume in the range 490-8580 fl. and containing 100-2000 platelets. The disappearance of single platelets and the formation of aggregates having volumes less than 490 fl. makes no significant contribution to the increase in light transmittance. Similar relationships are observed on addition of saturating doses of ADP and adrenaline except that the formation of aggregates larger than 8580 fl. contributes significantly to the initial phase of the increase in light transmittance and is more closely correlated with the overall change in this parameter. |
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| AbstractList | The increase in light transmittance of aspirin-treated platelet-rich plasma caused by addition of non-saturating doses of ADP and, at earlier times, of adrenaline is correlated with formation of aggregates having a volume in the range 490-8580 fl. and containing 100-2000 platelets. The disappearance of single platelets and the formation of aggregates having volumes less than 490 fl. makes no significant contribution to the increase in light transmittance. Similar relationships are observed on addition of saturating doses of ADP and adrenaline except that the formation of aggregates larger than 8580 fl. contributes significantly to the initial phase of the increase in light transmittance and is more closely correlated with the overall change in this parameter. |
| Author | Scrutton, M.C. Thompson, N.T. Wallis, R.B. |
| Author_xml | – sequence: 1 givenname: N.T. surname: Thompson fullname: Thompson, N.T. organization: Department of Biochemistry, King's College Strand, London WC2R 2LS, U.K – sequence: 2 givenname: M.C. surname: Scrutton fullname: Scrutton, M.C. organization: Department of Biochemistry, King's College Strand, London WC2R 2LS, U.K – sequence: 3 givenname: R.B. surname: Wallis fullname: Wallis, R.B. organization: Research Centre, Ciba-Geigy Pharmaceuticals, Wimblehurst Road, Horsham, West Sussex RH12 4AB, U.K |
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| Cites_doi | 10.1152/ajplegacy.1969.217.5.1330 10.3109/10408368309165759 10.1055/s-0038-1657259 10.1364/AO.22.001136 10.1016/0049-3848(85)90053-2 10.1055/s-0038-1666907 10.1016/0049-3848(79)90180-4 10.1152/jappl.1975.38.4.739 10.1055/s-0038-1650108 10.1111/j.1476-5381.1982.tb09210.x 10.1038/2151027a0 10.1111/j.1476-5381.1959.tb00928.x 10.1016/0049-3848(82)90118-9 |
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| Keywords | Platelet aggregate size Light transmittance ADP Adrenaline Aggregation Vertebrata Blood cell Platelet Mammalia Investigation method |
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| References | Cusack, Hourani (BIB4) 1982; 76 Born, Hume (BIB7) 1967; 215 Frojmovic, Duchastel, Milton (BIB15) 1983; 50 Reuter, Deters (BIB10) 1979; 15 Kitek, Breddin (BIB11) 1980; 44 Frojmovic (BIB19) 1982; 46 Thompson, Scrutton (BIB17) 1985; 38 Solis, Wright, Gibbs (BIB8) 1975; 38 Nicholls, Bosmann (BIB9) 1979; 42 Jurgens, Braunstein (BIB1) 1950; 80 Salzman, Ashford, Chambers, Neri, Dempster (BIB18) 1969; 217 Davis, Bown (BIB21) 1983; 245 O'Brien (BIB6) 1962; 15 Haver, Gear (BIB13) 1982; 48 Latimer (BIB16) 1983; 22 Arunlakshana, Schild (BIB3) 1959; 14 Gear (BIB12) 1982; 100 Frojmovic, Milton, Duchastel (BIB14) 1983; 101 Tiffany (BIB2) 1983; 19 Stuart (BIB5) 1978; 52 Yung, Frojmovic (BIB20) 1982; 28 Gear (10.1016/0049-3848(86)90358-0_BIB12) 1982; 100 Thompson (10.1016/0049-3848(86)90358-0_BIB17) 1985; 38 Davis (10.1016/0049-3848(86)90358-0_BIB21) 1983; 245 Yung (10.1016/0049-3848(86)90358-0_BIB20) 1982; 28 Tiffany (10.1016/0049-3848(86)90358-0_BIB2) 1983; 19 Haver (10.1016/0049-3848(86)90358-0_BIB13) 1982; 48 Jurgens (10.1016/0049-3848(86)90358-0_BIB1) 1950; 80 Frojmovic (10.1016/0049-3848(86)90358-0_BIB14) 1983; 101 Reuter (10.1016/0049-3848(86)90358-0_BIB10) 1979; 15 Frojmovic (10.1016/0049-3848(86)90358-0_BIB15) 1983; 50 Arunlakshana (10.1016/0049-3848(86)90358-0_BIB3) 1959; 14 Kitek (10.1016/0049-3848(86)90358-0_BIB11) 1980; 44 Latimer (10.1016/0049-3848(86)90358-0_BIB16) 1983; 22 Solis (10.1016/0049-3848(86)90358-0_BIB8) 1975; 38 Nicholls (10.1016/0049-3848(86)90358-0_BIB9) 1979; 42 Salzman (10.1016/0049-3848(86)90358-0_BIB18) 1969; 217 Stuart (10.1016/0049-3848(86)90358-0_BIB5) 1978; 52 Frojmovic (10.1016/0049-3848(86)90358-0_BIB19) 1982; 46 O'Brien (10.1016/0049-3848(86)90358-0_BIB6) 1962; 15 Cusack (10.1016/0049-3848(86)90358-0_BIB4) 1982; 76 Born (10.1016/0049-3848(86)90358-0_BIB7) 1967; 215 |
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Haemostas. doi: 10.1055/s-0038-1666907 contributor: fullname: Nicholls – volume: 15 start-page: 711 year: 1979 ident: 10.1016/0049-3848(86)90358-0_BIB10 article-title: Comparative investigations on the quantitative ive determination of ADP- and adrenaline-induced aggregation by means of a microscopic test and an electronic platelet counting method publication-title: Thromb. Res. doi: 10.1016/0049-3848(79)90180-4 contributor: fullname: Reuter – volume: 52 start-page: 299 issue: suppl. 1 year: 1978 ident: 10.1016/0049-3848(86)90358-0_BIB5 article-title: An assay for detecting platelet hyperfunction publication-title: Blood contributor: fullname: Stuart – volume: 38 start-page: 739 year: 1975 ident: 10.1016/0049-3848(86)90358-0_BIB8 article-title: Electronic particle size measurements of platelet aggregates formed in vitro publication-title: J. Applied Physiol. doi: 10.1152/jappl.1975.38.4.739 contributor: fullname: Solis – volume: 245 start-page: R776 year: 1983 ident: 10.1016/0049-3848(86)90358-0_BIB21 article-title: Analysis of platelet aggregation using particle collision theory publication-title: Am. J. Physiol. contributor: fullname: Davis – volume: 80 start-page: 1388 year: 1950 ident: 10.1016/0049-3848(86)90358-0_BIB1 article-title: Zur. Pathogenese der Thrombose publication-title: Schweiz. Med. Wochenschr. contributor: fullname: Jurgens – volume: 44 start-page: 154 year: 1980 ident: 10.1016/0049-3848(86)90358-0_BIB11 article-title: Optical density variations and microscopic observations in the evaluation of platelet shape change and microaggregate formation publication-title: Thromb. Haemost. doi: 10.1055/s-0038-1650108 contributor: fullname: Kitek – volume: 76 start-page: 221 year: 1982 ident: 10.1016/0049-3848(86)90358-0_BIB4 article-title: Adenosine 5'-diphosphate antagonists and human platelets: no evidence that aggregation and inhibition of stimulated adenylate cyclase are mediated by different receptors publication-title: Brit. J. Pharmacol. doi: 10.1111/j.1476-5381.1982.tb09210.x contributor: fullname: Cusack – volume: 215 start-page: 1027 year: 1967 ident: 10.1016/0049-3848(86)90358-0_BIB7 article-title: Effects of the numbers and sizes of platelet aggregates on the optical density of plasma publication-title: Nature doi: 10.1038/2151027a0 contributor: fullname: Born – volume: 14 start-page: 48 year: 1959 ident: 10.1016/0049-3848(86)90358-0_BIB3 article-title: Some quantitative uses of drug antagonists publication-title: Brit. J. Pharmacol. Chemotherap. doi: 10.1111/j.1476-5381.1959.tb00928.x contributor: fullname: Arunlakshana – volume: 101 start-page: 964 year: 1983 ident: 10.1016/0049-3848(86)90358-0_BIB14 article-title: Microscopic measurements of platelet aggregation reveal a low ADP-dependent process distinct from turbidometrically-measured aggregation publication-title: J. Lab. Clin. Med. contributor: fullname: Frojmovic – volume: 28 start-page: 361 year: 1982 ident: 10.1016/0049-3848(86)90358-0_BIB20 article-title: Platelet aggregation in laminar flow. I. Adenosine diphosphate concentration, time and shear rate dependence publication-title: Thromb. Res. doi: 10.1016/0049-3848(82)90118-9 contributor: fullname: Yung – volume: 50 start-page: 447 year: 1983 ident: 10.1016/0049-3848(86)90358-0_BIB15 article-title: Human platelet aggregation by particle counting (P.A.) II. Comparison of thrombin, serotonin and adrenaline with ADP publication-title: Thromb. Haemost. contributor: fullname: Frojmovic |
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| SubjectTerms | Adenosine Diphosphate - pharmacology ADP Adrenaline Biological and medical sciences Blood coagulation. Blood cells Epinephrine - pharmacology Fundamental and applied biological sciences. Psychology Humans In Vitro Techniques Light Light transmittance Molecular and cellular biology Particle Size Platelet Platelet aggregate size Platelet Aggregation - drug effects |
| Title | Particle volume changes associated with light transmittance changes in the platelet aggregometer: Dependence upon aggregating agent and effectiveness of stimulus |
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