High glucose induction of DNA-binding activity of the transcription factor NFκB in patients with diabetic nephropathy

• Published in: Biochimica et biophysica acta. Molecular basis of disease Vol. 1782; no. 5; pp. 295 - 302
• Main Authors: Yang, Bingmei, Hodgkinson, Andrea, Oates, Peter J., Millward, Beverley A., Demaine, Andrew G.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.05.2008; Elsevier
• Subjects: Aldose reductase; Aldose reductase inhibitor; Diabetic nephropathy; Nuclear factor kappa B; siRNA; Aldose reductase inhibitor; Diabetic nephropathy; siRNA; Aldose reductase; Nuclear factor kappa B; Life Sciences

The aim of this study was to investigate whether high glucose induces aldose reductase (AKR1B1) expression through NFκB, which may contribute to the pathogenesis of diabetic nephropathy. 34 Caucasoid patients with type 1 diabetes were recruited; 20 nephropaths and 14 long-term uncomplicated subjects...