Species specificity of the fibrinolytic effects of activated protein C

• Published in: Thrombosis research Vol. 63; no. 1; pp. 123 - 131
• Main Authors: Weinstein, Ralph E, Walker, Frederick J
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Ltd 01.07.1991; Elsevier Science
• Subjects: activated Protein C; Animals; Biological and medical sciences; Blood Coagulation - drug effects; Blood coagulation. Blood cells; Blood Proteins - pharmacology; Cattle; Coagulation; Fibrinolysis; Fibrinolysis - drug effects; Fundamental and applied biological sciences. Psychology; General aspects, investigation methods, hemostasis, fibrinolysis; Glycoproteins - pharmacology; Humans; In Vitro Techniques; Molecular and cellular biology; Plasminogen Activator Inhibitor; Plasminogen Inactivators - metabolism; Protein C - pharmacology; Protein S; Rabbits; Species Specificity; Tissue-Plasminogen activator; Plasminogen Activator Inhibitor; Tissue-Plasminogen activator; activated Protein C; Fibrinolysis; Coagulation; Human; Blood coagulation; Enzyme; Enzyme inhibitor; Rabbit; Plasminogen activator; Vitronectin; Activation; Lagomorpha; Biological activity; Blood plasma; Vertebrata; Mammalia; C reactive protein; Comparative study

Activated protein C (APC) has been shown to stimulate fibrinolysis in both in vitro and in vivo experimental systems. In order to test the importance of protein S in the fibrinolytic activity of APC we have compared the activity of APC, prepared from rabbit, bovine and human plasma, in the stimulati...