A standardized extract of the fruit of Hovenia dulcis alleviated alcohol-induced hangover in healthy subjects with heterozygous ALDH2: A randomized, controlled, crossover trial - Kim, Hoejin; Kim, You Jin; Jeong, Hye Yun; Kim, Ji Yeon; Choi, Eun-Kyung; Chae, Soo Wan; Kwon, Oran (Journal of ethnopharmacology, 2017)
Keywords: acetaldehyde; Adult; adults; Alcohol; alcohol drinking; Alcohol Drinking - adverse effects; alcohols; Aldehyde Dehydrogenase, Mitochondrial - genetics; alleles; aspartate transaminase; Biomarkers; blood sampling; correlation; Cross-Over Studies; Cytochrome P-450 CYP2E1 - genetics; East Asia; endotoxins; Fruit - chemistry; fruit extracts; Fruit of Hovenia dulcis Thunb; Genetic polymorphism; Genetic Predisposition to Disease; Hangover; heterozygosity; Heterozygote; Hovenia dulcis; Humans; Inflammation; interleukin-10; interleukin-6; Male; males; placebos; Plant Extracts - chemistry; Plant Extracts - pharmacology; Rhamnaceae - chemistry; Time Factors; traditional medicine; trees; Young Adult; East Asia; AST; CONSORT; sCD14; Hangover; ADH; HDE; ALT; Alcohol; Inflammation; IL-12; IL-6; IL-10; ALDH; IFN-γ; TNF-α; iAUC; Genetic polymorphism; CYP2E1; LBP; Fruit of Hovenia dulcis Thunb