Low bone mass in hypogonadal males. Effect of testosterone substitution therapy, a densitometric study
Sixteen (16) male patients who were suffering from hypogonadism but who were free from bone symptoms were recruited from the Andrology Clinic. Their bone mineral density (BMD) was assessed by single photon absorptiometry in the non-dominant radius, at both the distal radius (DR) (27% trabecular bone...
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Published in | Maturitas Vol. 15; no. 1; pp. 17 - 23 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
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Shannon
Elsevier Ireland Ltd
01.08.1992
Elsevier Science |
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Abstract | Sixteen (16) male patients who were suffering from hypogonadism but who were free from bone symptoms were recruited from the Andrology Clinic. Their bone mineral density (BMD) was assessed by single photon absorptiometry in the non-dominant radius, at both the distal radius (DR) (27% trabecular bone) and the midshaft radius (MR) (90% cortical bone). Measurements were carried out before and during testosterone substitution therapy. BMD was found to be lower in the subjects than in the controls, to a similar extent at both the DR (0.47 ± 0.02 g/cm
2, i.e. 83.1 ± 4.3% of the value in the controls, or Z score −1.42 ± 0.39;
P < 0.01) and the MR (0.68 ± 0.02 g/cm
2, i.e. 87.8 ± 2.4% of the value in the controls, or Z score −1.49 ± 0.33;
P < 0.01). There was no correlation between testosterone levels and BMD at either the DR or the MR at the beginning of the study. Following testosterone substitution therapy, bone mineral content (BMC) increased significantly at the DR (+5.9 ± 1.4% per year;
P < 0.01) and at the MR (+1.1 ± 0.9% per year;
P < 0.01). If the study is limited to the subjects who had achieved full bone age maturity before the start of therapy, the bone gain remains significant only at the DR, a site with a sizeable proportion of trabecular bone. |
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AbstractList | Sixteen (16) male patients who were suffering from hypogonadism but who were free from bone symptoms were recruited from the Andrology Clinic. Their bone mineral density (BMD) was assessed by single photon absorptiometry in the non-dominant radius, at both the distal radius (DR) (27% trabecular bone) and the midshaft radius (MR) (90% cortical bone). Measurements were carried out before and during testosterone substitution therapy. BMD was found to be lower in the subjects than in the controls, to a similar extent at both the DR (0.47 +/- 0.02 g/cm2, i.e. 83.1 +/- 4.3% of the value in the controls, or Z score -1.42 +/- 0.39; P less than 0.01) and the MR (0.68 +/- 0.02 g/cm2, i.e. 87.8 +/- 2.4% of the value in the controls, or Z score -1.49 +/- 0.33; P less than 0.01). There was no correlation between testosterone levels and BMD at either the DR or the MR at the beginning of the study. Following testosterone substitution therapy, bone mineral content (BMC) increased significantly at the DR (+5.9 +/- 1.4% per year; P less than 0.01) and at the MR (+1.1 +/- 0.9% per year; P less than 0.01). If the study is limited to the subjects who had achieved full bone age maturity before the start of therapy, the bone gain remains significant only at the DR, a site with a sizeable proportion of trabecular bone. Sixteen (16) male patients who were suffering from hypogonadism but who were free from bone symptoms were recruited from the Andrology Clinic. Their bone mineral density (BMD) was assessed by single photon absorptiometry in the non-dominant radius, at both the distal radius (DR) (27% trabecular bone) and the midshaft radius (MR) (90% cortical bone). Measurements were carried out before and during testosterone substitution therapy. BMD was found to be lower in the subjects than in the controls, to a similar extent at both the DR (0.47 ± 0.02 g/cm 2, i.e. 83.1 ± 4.3% of the value in the controls, or Z score −1.42 ± 0.39; P < 0.01) and the MR (0.68 ± 0.02 g/cm 2, i.e. 87.8 ± 2.4% of the value in the controls, or Z score −1.49 ± 0.33; P < 0.01). There was no correlation between testosterone levels and BMD at either the DR or the MR at the beginning of the study. Following testosterone substitution therapy, bone mineral content (BMC) increased significantly at the DR (+5.9 ± 1.4% per year; P < 0.01) and at the MR (+1.1 ± 0.9% per year; P < 0.01). If the study is limited to the subjects who had achieved full bone age maturity before the start of therapy, the bone gain remains significant only at the DR, a site with a sizeable proportion of trabecular bone. |
Author | Devogelaer, J.P. De Cooman, S. de Deuxchaisnes, C.Nagant |
Author_xml | – sequence: 1 givenname: J.P. surname: Devogelaer fullname: Devogelaer, J.P. organization: Departments of Rheumatology, St-Luc University Hospital, Louvain University in Brussels, Avenue Hippocrate 10, B-1200 Brussels Belgium – sequence: 2 givenname: S. surname: De Cooman fullname: De Cooman, S. organization: Departments of Andrology, St-Luc University Hospital, Louvain University in Brussels, Avenue Hippocrate 10, B-1200 Brussels Belgium – sequence: 3 givenname: C.Nagant surname: de Deuxchaisnes fullname: de Deuxchaisnes, C.Nagant organization: Departments of Rheumatology, St-Luc University Hospital, Louvain University in Brussels, Avenue Hippocrate 10, B-1200 Brussels Belgium |
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Keywords | bone mass osteodensitometry androgen therapy male hypogonadism Human Osteoporosis Chemotherapy Androgen Diseases of the osteoarticular system Male Sex steroid hormone Male genital diseases Hypogonadism |
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10.1016/S0140-6736(87)92255-0 contributor: fullname: Devogelaer |
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Snippet | Sixteen (16) male patients who were suffering from hypogonadism but who were free from bone symptoms were recruited from the Andrology Clinic. Their bone... |
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SubjectTerms | Adolescent Adult androgen therapy Biological and medical sciences Bone Density bone mass Delayed-Action Preparations Drug Combinations Gynecology. Andrology. Obstetrics Humans Hypogonadism - blood Hypogonadism - complications Hypogonadism - drug therapy Male Male genital diseases male hypogonadism Medical sciences Middle Aged Non tumoral diseases osteodensitometry Osteoporosis - diagnosis Osteoporosis - etiology Osteoporosis - pathology Testosterone - analogs & derivatives Testosterone - blood Testosterone - therapeutic use |
Title | Low bone mass in hypogonadal males. Effect of testosterone substitution therapy, a densitometric study |
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