Relationships among direct-acting mutagenicity, nitro group orientation and polarographic reduction potential of 6-nitrobenzo[ a]pyrene, 7-nitrobenz[ a]anthracene and their derivatives

• Published in: Mutation research Vol. 209; no. 3; pp. 115 - 122
• Main Authors: Fu, Peter P., Heflich, Robert H., Unruh, Leonard E., Shaikh, Ali U., Wu, Yu-Sen, Lai, Ching-Cheng, Lai, Jeng-Shiow
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.1988
• Subjects: 6-Nitrobenzo[ a]pyrene; 7-Nitro-benzo[ a]anthracene; Benz(a)Anthracenes - pharmacology; Benzopyrenes - pharmacology; Direct-acting mutagenicity; Molecular Structure; Mutagenicity Tests; Mutagens; Nitro group orientation; Oxidation-Reduction; Polarographic reduction potential; Polarography; Salmonella typhimurium - drug effects; 7-nitro-BA cis-5,6-dihydrodiol; 6-nitro-BaP cis-4,5-dihydrodiol; DMSO; 7-nitro-BA; TEAP; 6-nitro-BaP cis-4,5-diacetate; Direct-acting mutagenicity; 6-nitro-BaP; 6-Nitrobenzo[ a]pyrene; Nitro-PAHs; 7-Nitro-benzo[ a]anthracene; 7-nitro-BA cis-5,6-diacetate; Nitro group orientation; Polarographic reduction potential

The direct-acting mutagenicity in Salmonella typhimurium strains TA98 and TA100 and the half-wave reduction potentials of 6-nitrobenzo[ a]pyrene (6-nitro-BaP), 7-nitrobenz[ a]anthracene (7-nitro-BA), and a series of their derivatives were compared. The common structural feature of these compounds is...