Absence of cross‐reactivity to carbapenems in patients with delayed hypersensitivity to penicillins

• Published in: Allergy (Copenhagen) Vol. 68; no. 12; pp. 1618 - 1621
• Main Authors: Romano, A., Gaeta, F., Valluzzi, R. L., Alonzi, C., Maggioletti, M., Zaffiro, A., Caruso, C., Quaratino, D.
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.12.2013
• Subjects: Adolescent; Adult; Aged; Allergies; Antibiotics; carbapenems; Carbapenems - adverse effects; Cross Reactions - immunology; cross‐reactivity; Drug Hypersensitivity - diagnosis; Drug Hypersensitivity - immunology; Female; Humans; Hypersensitivity, Delayed - diagnosis; Hypersensitivity, Delayed - immunology; Hypersensitivity, Immediate - diagnosis; Hypersensitivity, Immediate - immunology; Male; Middle Aged; Penicillin; penicillin allergy; Penicillins - adverse effects; Prospective Studies; skin tests; Young Adult; skin tests; penicillin allergy; carbapenems; cross‐reactivity

Studies performed on subjects with IgE‐mediated hypersensitivity to penicillins have demonstrated a 1% rate of cross‐reactivity between penicillins and both imipenem and meropenem, while a single study found a 5.5% rate of cross‐reactivity with imipenem/cilastatin in subjects with T‐cell‐mediated hy...