Co-localization of N-acetyl-aspartyl-glutamate in central cholinergic, noradrenergic, and serotonergic neurons

• Published in: Synapse (New York, N.Y.) Vol. 1; no. 5; p. 455
• Main Authors: Forloni, G, Grzanna, R, Blakely, R D, Coyle, J T
• Format: Journal Article
• Language: English
• Published: United States 1987
• Subjects: Animals; Brain - cytology; Brain - enzymology; Choline O-Acetyltransferase - metabolism; Dipeptides - analysis; Dopamine beta-Hydroxylase - metabolism; Histocytochemistry; Immunohistochemistry; Male; Organ Specificity; Rats; Rats, Inbred Strains; Serotonin - analysis; Spinal Cord - cytology

An immunohistochemical technique for simultaneously visualizing two different antigens has been used to investigate the presence of the acidic dipeptide, N-acetyl-aspartyl-glutamate (NAAG), in cholinergic, noradrenergic-adrenergic, and serotonergic neurons within CNS. The brain slices were processed...