Phlebotomy or bloodletting: from tradition to evidence-based medicine

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Published in	Transfusion (Philadelphia, Pa.) Vol. 52; no. 3; pp. 460 - 462
Main Authors	Jhang, Jeffrey S., Schwartz, Joseph
Format	Journal Article
Language	English
Published	Malden, USA Blackwell Publishing Inc 01.03.2012
Subjects	Blood Component Removal - methods Erythrocytes Female Hemochromatosis - therapy Humans Male Phlebotomy - methods
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Author	Jhang, Jeffrey S. Schwartz, Joseph
Author_xml	– sequence: 1 givenname: Jeffrey S. surname: Jhang fullname: Jhang, Jeffrey S. organization: e-mail: jj222@columbia.edu – sequence: 2 givenname: Joseph surname: Schwartz fullname: Schwartz, Joseph organization: Columbia University Medical Center, Department of Pathology and Cell Biology, New York, NY
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Cites_doi	10.1016/j.bcmd.2003.08.003 10.1177/039139888901200110 10.1002/hep.21260 10.1093/aje/154.3.193 10.1053/j.gastro.2010.06.013 10.1136/bmj.286.6369.939 10.1007/BF01737944 10.1157/13092766 10.1053/gast.1996.v110.pm8613000 10.1182/blood-2011-01-258467 10.1016/0002-9149(84)90321-7 10.7326/0003-4819-145-3-200608010-00009 10.1038/ng1053 10.1046/j.1423-0410.2000.7910040.x 10.1038/75534 10.1002/jca.20240 10.1111/j.1537-2995.2011.03292.x 10.1016/S0002-9343(99)00120-5 10.1002/jca.10024 10.1136/jmg.34.4.275 10.1016/j.transci.2007.03.005 10.1182/blood-2010-01-261875
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Copyright	2011 American Association of Blood Banks
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References	Szczepiorkowski ZM, Winters JL, Bandarenko N, Kim HC, Linenberger ML, Marques MB, Sarode R, Schwartz J, Weinstein R, Shaz BH. Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the Apheresis Applications Committee of the American Society for Apheresis. J Clin Apher 2010;25:83-177. Merryweather-Clarke AT, Pointon JJ, Shearman JD, Robson KJ. Global prevalence of putative haemochromatosis mutations. J Med Genet 1997;34:275-8. Fernandez-Mosteirin N, Salvador-Osuna C, Garcia-Erce JA, Orna E, Perez-Lungmus G, Giralt M. [Comparison between phlebotomy and erythrocytapheresis of iron overload in patients with HFE gene mutations]. Med Clin (Barc) 2006;127:409-12. Davis WD Jr, Arrowsmith WR. The effect of repeated bleeding in Hemochromatosis. J Lab Clin Med 1950;36:814-5. Conte D, Brunelli L, Bozzani A, Tidone L, Quatrini M, Bianchi PA. Erythrocytapheresis in idiopathic haemochromatosis. Br Med J (Clin Res Ed) 1983;286:939. Roetto A, Papanikolaou G, Politou M, Alberti F, Girelli D, Christakis J, Loukopoulos D, Camaschella C. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet 2003;33:21-2. Camaschella C, Roetto A, Cali A, De Gobbi M, Garozzo G, Carella M, Majorano N, Totaro A, Gasparini P. The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22. Nat Genet 2000;25:14-5. Conte D, Mandelli C, Cesana M, Ferrini R, Marconi M, Bianchi A. Effectiveness of erythrocytapheresis in idiopathic hemochromatosis. Report of 14 cases. Int J Artif Organs 1989;12:59-62. Pietrangelo A. Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment. Gastroenterology 2010;139:393-408, e1-2. Greenstone G. The history of bloodletting. BCMJ 2010;52:12-4. Pietrangelo A. The ferroportin disease. Blood Cells Mol Dis 2004;32:131-8. Zoller WG, Kellner H, Spengel FA. Erythrocytapheresis. A method for rapid extracorporeal elimination of erythrocytes. Results in 65 patients. Klin Wochenschr 1988;66:404-9. Muncunill J, Vaquer P, Galmes A, Obrador A, Parera M, Bargay J, Besalduch J. In hereditary hemochromatosis, red cell apheresis removes excess iron twice as fast as manual whole blood phlebotomy. J Clin Apher 2002;17:88-92. Rombout-Sestrienkova E, van Noord PA, van Deursen CT, Sybesma BJ, Nillesen-Meertens AE, Koek GH. Therapeutic erythrocytapheresis versus phlebotomy in the initial treatment of hereditary hemochromatosis-a pilot study. Transfus Apher Sci 2007;36:261-7. Hanson EH, Imperatore G, Burke W. HFE gene and hereditary hemochromatosis: a HuGE review. Human Genome Epidemiology. Am J Epidemiol 2001;154:193-206. Niederau C, Fischer R, Purschel A, Stremmel W, Haussinger D, Strohmeyer G. Long-term survival in patients with hereditary hemochromatosis. Gastroenterology 1996;110:1107-19. Kellner H, Zoller WG. Repeated isovolemic large-volume erythrocytapheresis in the treatment of idiopathic hemochromatosis. Z Gastroenterol 1992;30:779-83. Rombout-Sestrienkova E, Nieman FHM, Essers BAB, van Noord PAH, Janssen MCH, van Deursen CThBM, Bos LP, Rombout F, van den Braak R, de Leeuw PW, Koek GH. Erythrocytapheresis versus phlebotomy in the initial treatment of HFE hemochromatosis patients: results from a randomized trial. Transfusion 2012;52:470-7. Kohan A, Niborski R, Daruich J, Rey J, Bastos F, Amerise G, Herrera R, Garcia M, Olivera W, Santarelli MT, Avalos JS, Findor J. Erythrocytapheresis with recombinant human erythropoietin in hereditary hemochromatosis therapy: a new alternative. Vox Sang 2000;79:40-5. Mariani R, Pelucchi S, Perseghin P, Corengia C, Piperno A. Erythrocytapheresis plus erythropoietin: an alternative therapy for selected patients with hemochromatosis and severe organ damage. Haematologica 2005;90:717-8. Ganz T. Hepcidin and iron regulation, 10 years later. Blood 2011;117:4425-33. Politou M, Kalotychou V, Pissia M, Rombos Y, Sakellaropoulos N, Papanikolaou G. The impact of the mutations of the HFE gene and of the SLC11A3 gene on iron overload in Greek thalassemia intermedia and beta(s)/beta(thal) anemia patients. Haematologica 2004;89:490-2. Whitlock EP, Garlitz BA, Harris EL, Beil TL, Smith PR. Screening for hereditary hemochromatosis: a systematic review for the U.S. Preventive Services Task Force. Ann Intern Med 2006;145:209-23. McDonnell SM, Preston BL, Jewell SA, Barton JC, Edwards CQ, Adams PC, Yip R. A survey of 2851 patients with hemochromatosis: symptoms and response to treatment. Am J Med 1999;106:619-24. Falize L, Guillygomarc'h A, Perrin M, Laine F, Guyader D, Brissot P, Turlin B, Deugnier Y. Reversibility of hepatic fibrosis in treated genetic hemochromatosis: a study of 36 cases. Hepatology 2006;44:472-7. Dabestani A, Child JS, Henze E, Perloff JK, Schon H, Figueroa WG, Schelbert HR, Thessomboon S. Primary hemochromatosis: anatomic and physiologic characteristics of the cardiac ventricles and their response to phlebotomy. Am J Cardiol 1984;54:153-9. Adams PC, Barton JC. How I treat hemochromatosis. Blood 2010;116:317-25. 2002; 17 2011; 117 2000; 25 2005; 90 2004; 89 1999; 106 2007; 36 2012; 52 2003; 33 1992; 30 2004; 32 2001; 154 1989; 12 1950; 36 2010; 25 1983; 286 2010; 116 2000; 79 2010; 139 2006; 44 1984; 54 1997; 34 1988; 66 1996; 110 2006; 127 2010; 52 2006; 145 Kellner H (e_1_2_3_8_2) 1992; 30 e_1_2_3_19_2 e_1_2_3_5_2 e_1_2_3_15_2 e_1_2_3_4_2 e_1_2_3_16_2 e_1_2_3_3_2 e_1_2_3_18_2 e_1_2_3_9_2 e_1_2_3_11_2 e_1_2_3_12_2 e_1_2_3_7_2 e_1_2_3_13_2 e_1_2_3_6_2 e_1_2_3_14_2 Davis WD (e_1_2_3_23_2) 1950; 36 Mariani R (e_1_2_3_10_2) 2005; 90 Politou M (e_1_2_3_17_2) 2004; 89 e_1_2_3_26_2 e_1_2_3_27_2 e_1_2_3_28_2 e_1_2_3_22_2 e_1_2_3_24_2 e_1_2_3_25_2 Greenstone G (e_1_2_3_2_2) 2010; 52 e_1_2_3_20_2 e_1_2_3_21_2 21848963 - Transfusion. 2012 Mar;52(3):470-7
References_xml	– reference: Niederau C, Fischer R, Purschel A, Stremmel W, Haussinger D, Strohmeyer G. Long-term survival in patients with hereditary hemochromatosis. Gastroenterology 1996;110:1107-19. – reference: Szczepiorkowski ZM, Winters JL, Bandarenko N, Kim HC, Linenberger ML, Marques MB, Sarode R, Schwartz J, Weinstein R, Shaz BH. Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the Apheresis Applications Committee of the American Society for Apheresis. J Clin Apher 2010;25:83-177. – reference: Fernandez-Mosteirin N, Salvador-Osuna C, Garcia-Erce JA, Orna E, Perez-Lungmus G, Giralt M. [Comparison between phlebotomy and erythrocytapheresis of iron overload in patients with HFE gene mutations]. Med Clin (Barc) 2006;127:409-12. – reference: Conte D, Mandelli C, Cesana M, Ferrini R, Marconi M, Bianchi A. Effectiveness of erythrocytapheresis in idiopathic hemochromatosis. Report of 14 cases. Int J Artif Organs 1989;12:59-62. – reference: Greenstone G. The history of bloodletting. BCMJ 2010;52:12-4. – reference: Pietrangelo A. The ferroportin disease. Blood Cells Mol Dis 2004;32:131-8. – reference: Merryweather-Clarke AT, Pointon JJ, Shearman JD, Robson KJ. Global prevalence of putative haemochromatosis mutations. J Med Genet 1997;34:275-8. – reference: Whitlock EP, Garlitz BA, Harris EL, Beil TL, Smith PR. Screening for hereditary hemochromatosis: a systematic review for the U.S. Preventive Services Task Force. Ann Intern Med 2006;145:209-23. – reference: Ganz T. Hepcidin and iron regulation, 10 years later. Blood 2011;117:4425-33. – reference: Rombout-Sestrienkova E, van Noord PA, van Deursen CT, Sybesma BJ, Nillesen-Meertens AE, Koek GH. Therapeutic erythrocytapheresis versus phlebotomy in the initial treatment of hereditary hemochromatosis-a pilot study. Transfus Apher Sci 2007;36:261-7. – reference: Politou M, Kalotychou V, Pissia M, Rombos Y, Sakellaropoulos N, Papanikolaou G. The impact of the mutations of the HFE gene and of the SLC11A3 gene on iron overload in Greek thalassemia intermedia and beta(s)/beta(thal) anemia patients. Haematologica 2004;89:490-2. – reference: Pietrangelo A. Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment. Gastroenterology 2010;139:393-408, e1-2. – reference: Conte D, Brunelli L, Bozzani A, Tidone L, Quatrini M, Bianchi PA. Erythrocytapheresis in idiopathic haemochromatosis. Br Med J (Clin Res Ed) 1983;286:939. – reference: McDonnell SM, Preston BL, Jewell SA, Barton JC, Edwards CQ, Adams PC, Yip R. A survey of 2851 patients with hemochromatosis: symptoms and response to treatment. Am J Med 1999;106:619-24. – reference: Adams PC, Barton JC. How I treat hemochromatosis. Blood 2010;116:317-25. – reference: Kellner H, Zoller WG. Repeated isovolemic large-volume erythrocytapheresis in the treatment of idiopathic hemochromatosis. Z Gastroenterol 1992;30:779-83. – reference: Rombout-Sestrienkova E, Nieman FHM, Essers BAB, van Noord PAH, Janssen MCH, van Deursen CThBM, Bos LP, Rombout F, van den Braak R, de Leeuw PW, Koek GH. Erythrocytapheresis versus phlebotomy in the initial treatment of HFE hemochromatosis patients: results from a randomized trial. Transfusion 2012;52:470-7. – reference: Dabestani A, Child JS, Henze E, Perloff JK, Schon H, Figueroa WG, Schelbert HR, Thessomboon S. Primary hemochromatosis: anatomic and physiologic characteristics of the cardiac ventricles and their response to phlebotomy. Am J Cardiol 1984;54:153-9. – reference: Roetto A, Papanikolaou G, Politou M, Alberti F, Girelli D, Christakis J, Loukopoulos D, Camaschella C. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet 2003;33:21-2. – reference: Davis WD Jr, Arrowsmith WR. The effect of repeated bleeding in Hemochromatosis. J Lab Clin Med 1950;36:814-5. – reference: Falize L, Guillygomarc'h A, Perrin M, Laine F, Guyader D, Brissot P, Turlin B, Deugnier Y. Reversibility of hepatic fibrosis in treated genetic hemochromatosis: a study of 36 cases. Hepatology 2006;44:472-7. – reference: Mariani R, Pelucchi S, Perseghin P, Corengia C, Piperno A. Erythrocytapheresis plus erythropoietin: an alternative therapy for selected patients with hemochromatosis and severe organ damage. Haematologica 2005;90:717-8. – reference: Muncunill J, Vaquer P, Galmes A, Obrador A, Parera M, Bargay J, Besalduch J. In hereditary hemochromatosis, red cell apheresis removes excess iron twice as fast as manual whole blood phlebotomy. J Clin Apher 2002;17:88-92. – reference: Camaschella C, Roetto A, Cali A, De Gobbi M, Garozzo G, Carella M, Majorano N, Totaro A, Gasparini P. The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22. Nat Genet 2000;25:14-5. – reference: Kohan A, Niborski R, Daruich J, Rey J, Bastos F, Amerise G, Herrera R, Garcia M, Olivera W, Santarelli MT, Avalos JS, Findor J. Erythrocytapheresis with recombinant human erythropoietin in hereditary hemochromatosis therapy: a new alternative. Vox Sang 2000;79:40-5. – reference: Zoller WG, Kellner H, Spengel FA. Erythrocytapheresis. A method for rapid extracorporeal elimination of erythrocytes. Results in 65 patients. Klin Wochenschr 1988;66:404-9. – reference: Hanson EH, Imperatore G, Burke W. HFE gene and hereditary hemochromatosis: a HuGE review. Human Genome Epidemiology. Am J Epidemiol 2001;154:193-206. – volume: 36 start-page: 261 year: 2007 end-page: 7 article-title: Therapeutic erythrocytapheresis versus phlebotomy in the initial treatment of hereditary hemochromatosis—a pilot study publication-title: Transfus Apher Sci – volume: 52 start-page: 12 year: 2010 end-page: 4 article-title: The history of bloodletting publication-title: BCMJ – volume: 30 start-page: 779 year: 1992 end-page: 83 article-title: Repeated isovolemic large‐volume erythrocytapheresis in the treatment of idiopathic hemochromatosis publication-title: Z Gastroenterol – volume: 36 start-page: 814 year: 1950 end-page: 5 article-title: The effect of repeated bleeding in Hemochromatosis publication-title: J Lab Clin Med – volume: 52 start-page: 470 year: 2012 end-page: 7 article-title: Erythrocytapheresis versus phlebotomy in the initial treatment of HFE hemochromatosis patients: results from a randomized trial publication-title: Transfusion – volume: 32 start-page: 131 year: 2004 end-page: 8 article-title: The ferroportin disease publication-title: Blood Cells Mol Dis – volume: 116 start-page: 317 year: 2010 end-page: 25 article-title: How I treat hemochromatosis publication-title: Blood – volume: 33 start-page: 21 year: 2003 end-page: 2 article-title: Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis publication-title: Nat Genet – volume: 139 start-page: 393 year: 2010 end-page: 408 article-title: Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment publication-title: Gastroenterology – volume: 117 start-page: 4425 year: 2011 end-page: 33 article-title: Hepcidin and iron regulation, 10 years later publication-title: Blood – volume: 25 start-page: 14 year: 2000 end-page: 5 article-title: The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22 publication-title: Nat Genet – volume: 25 start-page: 83 year: 2010 end-page: 177 article-title: Guidelines on the use of therapeutic apheresis in clinical practice–evidence‐based approach from the Apheresis Applications Committee of the American Society for Apheresis publication-title: J Clin Apher – volume: 286 start-page: 939 year: 1983 article-title: Erythrocytapheresis in idiopathic haemochromatosis publication-title: Br Med J (Clin Res Ed) – volume: 44 start-page: 472 year: 2006 end-page: 7 article-title: Reversibility of hepatic fibrosis in treated genetic hemochromatosis: a study of 36 cases publication-title: Hepatology – volume: 127 start-page: 409 year: 2006 end-page: 12 article-title: [Comparison between phlebotomy and erythrocytapheresis of iron overload in patients with HFE gene mutations] publication-title: Med Clin (Barc) – volume: 145 start-page: 209 year: 2006 end-page: 23 article-title: Screening for hereditary hemochromatosis: a systematic review for the U.S. Preventive Services Task Force publication-title: Ann Intern Med – volume: 12 start-page: 59 year: 1989 end-page: 62 article-title: Effectiveness of erythrocytapheresis in idiopathic hemochromatosis. Report of 14 cases publication-title: Int J Artif Organs – volume: 90 start-page: 717 year: 2005 end-page: 8 article-title: Erythrocytapheresis plus erythropoietin: an alternative therapy for selected patients with hemochromatosis and severe organ damage publication-title: Haematologica – volume: 154 start-page: 193 year: 2001 end-page: 206 article-title: HFE gene and hereditary hemochromatosis: a HuGE review. Human Genome Epidemiology publication-title: Am J Epidemiol – volume: 106 start-page: 619 year: 1999 end-page: 24 article-title: A survey of 2851 patients with hemochromatosis: symptoms and response to treatment publication-title: Am J Med – volume: 17 start-page: 88 year: 2002 end-page: 92 article-title: In hereditary hemochromatosis, red cell apheresis removes excess iron twice as fast as manual whole blood phlebotomy publication-title: J Clin Apher – volume: 34 start-page: 275 year: 1997 end-page: 8 article-title: Global prevalence of putative haemochromatosis mutations publication-title: J Med Genet – volume: 66 start-page: 404 year: 1988 end-page: 9 article-title: Erythrocytapheresis. A method for rapid extracorporeal elimination of erythrocytes. 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SubjectTerms	Blood Component Removal - methods Erythrocytes Female Hemochromatosis - therapy Humans Male Phlebotomy - methods
Title	Phlebotomy or bloodletting: from tradition to evidence-based medicine
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