A Convenient and Effective Method for the Regioselective Deuteration of Alcohols

The convenient and regioselective deuteration of hydroxy groups on vicinal carbons was achieved by the combination of 5% ruthenium on carbon (Ru/C), hydrogen gas and deuterium oxide (D2O).

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 350; no. 14‐15; pp. 2215 - 2218
Main Authors Maegawa, Tomohiro, Fujiwara, Yuta, Inagaki, Yuya, Monguchi, Yasunari, Sajiki, Hironao
Format Journal Article
LanguageEnglish
Published Weinheim WILEY‐VCH Verlag 06.10.2008
Wiley
Subjects
alcohols
Chemistry
Chemistry, Applied
Chemistry, Organic
deuteration
heterogeneous catalysis
Physical Sciences
regioselectivity
ruthenium
Science & Technology
regioselectivity
deuteration
heterogeneous catalysis
HETEROGENEOUS PD/C
alcohols
EFFICIENT H/D EXCHANGE
AROMATIC-COMPOUNDS
MASS-SPECTROMETRY
AQUEOUS-SOLUTION
H BOND ACTIVATION
SECONDARY ALCOHOLS
ruthenium
DEUTERIUM-OXIDE
D EXCHANGE-REACTION
DERIVATIVES
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Summary:The convenient and regioselective deuteration of hydroxy groups on vicinal carbons was achieved by the combination of 5% ruthenium on carbon (Ru/C), hydrogen gas and deuterium oxide (D2O).
Bibliography:ObjectType-Article-2
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ObjectType-Feature-1
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ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200800407