Nocardia seriolae mediates liver granulomatous chronic inflammation in Micropterus salmoides through pyroptosis

• Published in: Journal of fish diseases Vol. 46; no. 4; pp. 321 - 332
• Main Authors: Zhou, Zheng‐Yang, Bai, Shang‐Jie, Lu, Chen‐Wang, Yang, Bin, Wang, Jun, Lian, Sheng, Jian, Zheng‐Ran, Wang, Er‐Long, Wang, Gao‐Xue, Liu, Tao
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.04.2023
• Subjects: Animals; Bass; Chronic infection; Cultured organisms; Cytokines; farmed fish; Fish; Fish culture; Fish diseases; Fish Diseases - microbiology; Flow cytometry; fluorescent antibody technique; Granuloma; Granulomas; Immunofluorescence; Infections; Inflammation; Inflammation - veterinary; Liver; Liver - pathology; Macrophages; Micropterus salmoides; Molecular modelling; Nocardia; Nocardia Infections - microbiology; Nocardia seriolae; nocardiosis; Pathogenesis; Proteins; Pyroptosis; Transcription; Transcription factors; Nocardia seriolae; Micropterus salmoides; pyroptosis; granuloma

Granulomatous diseases caused by Nocardia seriously endanger the health of cultured fish. These bacteria are widely distributed, but prevention and treatment methods are very limited. Chronic granulomatous inflammation is an important pathological feature of Nocardia infection. However, the molecula...