Functional impairment of myeloid and plasmacytoid dendritic cells of patients with chronic hepatitis B

• Published in: Hepatology (Baltimore, Md.) Vol. 40; no. 3; pp. 738 - 746
• Main Authors: van der Molen, Renate G., Sprengers, Dave, Binda, Rekha S., de Jong, Esther C., Niesters, Hubert G. M., Kusters, Johannes G., Kwekkeboom, Jaap, Janssen, Harry L. A.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2004; Wiley
• Subjects: Alanine Transaminase - blood; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antigens, CD - analysis; Antiviral agents; B7-1 Antigen - analysis; B7-2 Antigen; Biological and medical sciences; Dendritic Cells - physiology; DNA, Viral - analysis; Hematopoietic Stem Cells - physiology; Hematopoietic Stem Cells - virology; Hepatitis B, Chronic - immunology; Human viral diseases; Humans; Infectious diseases; Interferon-alpha - biosynthesis; Medical sciences; Membrane Glycoproteins - analysis; Pharmacology. Drug treatments; Tumor Necrosis Factor-alpha - biosynthesis; Viral diseases; Viral diseases of the digestive system; Viral hepatitis; Viral Load; Cell function; Orthohepadnavirus; Check; Hepatic disease; Precursor; Blood; Prevention; Viral hepatitis B; Mononuclear cell; Immunological investigation; Hepadnaviridae; T-Lymphocyte; Antiviral; Hepatitis B virus; Human; Dendritic cell; Healthy subject; Myeloid cell; In vitro; Infection; Virus; Blood cell; Phenotype; Viral disease; Bacteriosis; Digestive diseases; Staphylococcal infection; Comparative study

Dendritic cells (DC) play an important role in the induction of T‐cell responses. We hypothesize that the hampered antiviral T‐cell response in chronic hepatitis B patients is a result of impaired dendritic cell function. In this study, we compared the number, phenotype and functionality of two impo...