Human salivary gland cells express bradykinin receptors that modulate the expression of proinflammatory cytokines

• Published in: European journal of oral sciences Vol. 125; no. 1; pp. 18 - 27
• Main Authors: Lee, Keimin, Kim, Yoon‐Jung, Choi, La‐Mee, Choi, Seulki, Nam, Hyun, Ko, Hui‐Yeon, Chung, Gehoon, Lee, Jong‐Ho, Jo, Su‐Hyun, Lee, Gene, Choi, Se‐Young, Park, Kyungpyo
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.02.2017
• Subjects: Adult; Aged; Aged, 80 and over; aquaporin; Aquaporin 5 - metabolism; Blotting, Western; Bradykinin; Bradykinin - analogs & derivatives; Bradykinin - pharmacology; Bradykinin B2 receptors; Bradykinin receptors; Calcium (intracellular); Calcium - metabolism; Calcium signalling; Carbachol; Carbachol - pharmacology; Cell Line; Cells, Cultured; Cyclic AMP - metabolism; cytokine; Cytokines; Cytokines - metabolism; Data processing; Dentistry; Female; Fluorescent Antibody Technique; G protein-coupled receptors; Glands; human submandibular gland; Humans; Immune system; Inflammation; intracellular calcium; Male; Middle Aged; Real-Time Polymerase Chain Reaction; Receptors; Receptors, Bradykinin - metabolism; Salivary gland; Salivary glands; Salivary Glands - cytology; Salivary Glands - metabolism; Signal Transduction; Submandibular gland; Translocation; Tumor necrosis factor; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; cytokine; bradykinin; intracellular calcium; aquaporin; human submandibular gland

Bradykinin is an important peptide modulator that affects the function of neurons and immune cells. However, there is no evidence of the bradykinin receptors and their functions in human salivary glands. Here we have identified and characterized bradykinin receptors on human submandibular gland cell...