Regulation of myeloperoxidase‐specific T cell responses during disease remission in antineutrophil cytoplasmic antibody–associated vasculitis: The role of Treg cells and tryptophan degradation

• Published in: Arthritis and rheumatism Vol. 62; no. 5; pp. 1539 - 1548
• Main Authors: Chavele, Konstantia‐Maria, Shukla, Deepa, Keteepe‐Arachi, Tracey, Seidel, Judith Anna, Fuchs, Dietmar, Pusey, Charles D., Salama, Alan D.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.05.2010; Wiley
• Subjects: Acute Disease; Adeno-associated virus; Aged; Antibodies, Antineutrophil Cytoplasmic - immunology; Biological and medical sciences; Biomarkers - blood; Diseases of the osteoarticular system; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunosuppressive Agents - therapeutic use; Kynurenine - blood; Lymphocyte Count; Male; Medical sciences; Middle Aged; Neopterin - blood; Peroxidase - metabolism; Remission Induction; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; T-Lymphocytes, Regulatory - enzymology; T-Lymphocytes, Regulatory - immunology; Tryptophan - blood; Vasculitis - drug therapy; Vasculitis - immunology; Vasculitis - metabolism; Antineutrophil cytoplasmic antibody; Enzyme; Rheumatology; Tryptophan; Cardiovascular disease; Vascular disease; Vasculitis; Peroxidases; Immunological investigation; T-Lymphocyte; Remission; Peroxidase; Oxidoreductases

Objective T lymphocytes have been implicated in the pathogenesis of antineutrophil cytoplasmic antibody–associated vasculitis (AAV). Patients with myeloperoxidase (MPO) antineutrophil cytoplasmic antibody (ANCA) experience relapses less frequently than those with proteinase 3 ANCA, suggesting greate...