Cancer‐associated molecular signature in the tissue samples of patients with cirrhosis

• Published in: Hepatology (Baltimore, Md.) Vol. 39; no. 2; pp. 518 - 527
• Main Authors: Kim, Jin Woo, Ye, Qinghai, Forgues, Marshonna, Chen, Yidong, Budhu, Anuradha, Sime, Jessica, Hofseth, Lorne J., Kaul, Rashmi, Wang, Xin Wei
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.02.2004; Wiley
• Subjects: Antigens, Neoplasm - genetics; Biological and medical sciences; Carcinoma, Hepatocellular - epidemiology; Carcinoma, Hepatocellular - genetics; Cell Adhesion Molecules - genetics; Epithelial Cell Adhesion Molecule; Gastroenterology. Liver. Pancreas. Abdomen; Gene Expression Regulation, Neoplastic; Humans; Liver Cirrhosis - epidemiology; Liver Cirrhosis - etiology; Liver Cirrhosis - genetics; Liver Neoplasms - epidemiology; Liver Neoplasms - genetics; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; Oligonucleotide Array Sequence Analysis; Other diseases. Semiology; Risk Factors; Human; Cirrhosis; Tissue; Sample; Gastroenterology; Digestive diseases; Hepatic disease; Malignant tumor

Several types of aggressive cancers, including hepatocellular carcinoma (HCC), often arise as a multifocal primary tumor. This suggests a high rate of premalignant changes in noncancerous tissue before the formation of a solitary tumor. Examination of the messenger RNA expression profiles of tissue...