Mutation in the S gene a determinant of the hepatitis B virus associated with concomitant HBsAg and anti‐HBs in a population in Northeastern Brazil

• Published in: Journal of medical virology Vol. 89; no. 3; pp. 458 - 462
• Main Authors: de Campos Albuquerque, Ingrid, Sousa, Marinilde Teles, Santos, Max Diego Cruz, Nunes, Jomar Diogo Costa, Moraes, Maria Josélia Diniz, Gomes‐Gouvêa, Michele Soares, Pinho, João Renato Rebelo, Carrilho, Flair José, Fonseca, Lena Maria Barros, de Sousa Paiva Ferreira, Adalgisa
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.03.2017
• Subjects: Adult; antibody; Brazil - epidemiology; Cross-Sectional Studies; DNA, Viral - blood; Female; HBsAg; hepatitis B; Hepatitis B - diagnosis; Hepatitis B - epidemiology; Hepatitis B - virology; Hepatitis B Antibodies - blood; Hepatitis B Surface Antigens - blood; Hepatitis B Surface Antigens - genetics; Hepatitis B virus; Hepatitis B virus - genetics; Hepatitis B virus - immunology; Humans; Male; Middle Aged; Mutation; Sequence Analysis, DNA; Seroepidemiologic Studies; Viral Load; Virology; mutation; HBsAg; antibody; hepatitis B

Mutations in the a determinant of S gene may develop co‐existence of hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti‐HBs) in the serum of infected hepatitis B virus (HBV) individuals. Mutations in this region may change the antigenicity of HBsAg, which in turn, lead to escape of ne...