For t 2 DNA vaccine prevents Forcipomyia taiwana (biting midge) allergy in a mouse model

• Published in: Allergy (Copenhagen) Vol. 71; no. 4; pp. 522 - 531
• Main Authors: Lee, M.‐F., Song, P.‐P., Lin, T.‐M., Chiu, Y.‐T., Chen, Y.‐H.
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.04.2016
• Subjects: allergy; animal models; Animals; Antibodies - immunology; Antibody Specificity - immunology; Ceratopogonidae - genetics; Ceratopogonidae - immunology; Cytokines - metabolism; Disease Models, Animal; Female; Forcipomyia; Gene Expression; Hypersensitivity - etiology; Hypersensitivity - metabolism; Hypersensitivity - prevention & control; Hypersensitivity, Delayed - etiology; Hypersensitivity, Delayed - metabolism; Hypersensitivity, Delayed - prevention & control; immunotherapy and tolerance induction; Insect Bites and Stings - immunology; Insect Proteins - genetics; Insect Proteins - immunology; Mice; Recombinant Proteins - genetics; Recombinant Proteins - immunology; Skin - immunology; Skin - metabolism; Skin - pathology; Vaccines, DNA - administration & dosage; Vaccines, DNA - immunology; venom and insect; venom and insect; allergy; animal models; immunotherapy and tolerance induction

Background Forcipomyia taiwana (biting midge) is the most prevalent allergenic biting insect in Taiwan, and 60% of the exposed subjects develop allergic reactions. Subjects with insect allergy frequently limit their outdoor activities to avoid the annoyingly intense itchy allergic reactions, leading...