Radiosynthesis of a Bruton's tyrosine kinase inhibitor, [11C]Tolebrutinib, via palladium‐NiXantphos‐mediated carbonylation - Dahl, Kenneth; Turner, Timothy; Vasdev, Neil (Journal of labelled compounds & radiopharmaceuticals, 2020)
Keywords: Acrylamide; Agammaglobulinaemia Tyrosine Kinase - antagonists & inhibitors; aminocarbonylation; Biochemical Research Methods; Biochemistry & Molecular Biology; Bruton's tyrosine kinase; BTK; Carbon monoxide; Carbon Radioisotopes - chemistry; Carbonyls; carbon‐11; Chemistry; Chemistry Techniques, Synthetic; Chemistry, Analytical; Chemistry, Medicinal; Emission analysis; Enzyme inhibitors; Kinases; Life Sciences & Biomedicine; Medical imaging; Multiple sclerosis; Palladium; Palladium - chemistry; PET; Pharmacology & Pharmacy; Physical Sciences; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Protein Kinase Inhibitors - chemical synthesis; Protein Kinase Inhibitors - chemistry; Radiochemistry; Radiopharmaceuticals - chemical synthesis; Radiopharmaceuticals - chemistry; Science & Technology; Signal transduction; Synthesis; Target recognition; Tomography; Tyrosine; Tyrosine kinase inhibitors; ACID; C-11-CARBONYLATION; MONOXIDE; BTK; carbon-11; PET; radiochemistry; LABELING CHEMISTRY; aminocarbonylation