Mitochondrial dysfunction in osteoarthritis is associated with down‐regulation of superoxide dismutase 2

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 65; no. 2; pp. 378 - 387
• Main Authors: Gavriilidis, Christos, Miwa, Satomi, von Zglinicki, Thomas, Taylor, Robert W., Young, David A.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.02.2013; Wiley Subscription Services, Inc
• Subjects: Cartilage, Articular - enzymology; Cells, Cultured; Chondrocytes - enzymology; Down-Regulation; Humans; Lipid Peroxidation; Lipids; Mitochondria - enzymology; Mitochondria - genetics; Mitochondrial DNA; Osteoarthritis - enzymology; Osteoarthritis - genetics; Reactive Oxygen Species - metabolism; Superoxide Dismutase - genetics; Superoxide Dismutase - metabolism

Objective Superoxide dismutase 2 (SOD2) is down‐ regulated in osteoarthritis (OA). This study was undertaken to investigate the functional effects of this down‐regulation in the context of oxidative damage and mitochondrial dysfunction. Methods Lipid peroxidation in articular cartilage from OA patie...