Nickel‐induced VEGF expression via regulation of Akt, ERK1/2, NFκB, and AMPK pathways in H460 cells

• Published in: Environmental toxicology Vol. 34; no. 5; pp. 652 - 658
• Main Authors: Wang, Jui‐Chin, Chen, Shih‐Yin, Wang, Meilin, Ko, Jiunn‐Liang, Wu, Chieh‐Lin, Chen, Ching‐Chung, Lin, Hui‐Wen, Chang, Yuan‐Yen
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.05.2019; Wiley Subscription Services, Inc
• Subjects: 1-Phosphatidylinositol 3-kinase; Activation; AKT protein; AMP; AMP-activated protein kinase; Angiogenesis; Cancer; Cells; cohort studies; Cohorts; Enzyme inhibitors; Exposure; Extracellular; Extracellular signal-regulated kinase; Growth factors; human health; human non‐small‐cell lung cancer (NSCLC) H460 cells; humans; Inhibitors; Kinases; Lung cancer; lung neoplasms; Lungs; MAP kinase; mitogen-activated protein kinase; NF-κB protein; Nickel; Nickel chloride; nickel chloride (NiCl2); Nickel compounds; non-specific serine/threonine protein kinase; Phosphorylation; Proteins; respiratory system; Respiratory tract; Signal transduction; transcription factor NF-kappa B; Vascular endothelial growth factor; vascular endothelial growth factor (VEGF); vascular endothelial growth factors; vascular endothelial growth factor (VEGF); nickel chloride (NiCl2); human non-small-cell lung cancer (NSCLC) H460 cells

Prospective cohort studies have indicated that a highly nickel‐polluted environment may severely affect human health, resulting in such conditions as respiratory tract cancers. Such exposure can trigger vascular endothelial growth factor (VEGF) expression. However, the signal transduction pathways l...