Curcumin suppresses cell proliferation and triggers apoptosis in vemurafenib‐resistant melanoma cells by downregulating the EGFR signaling pathway - Chiu, Yu‐Jen; Yang, Jai‐Sing; Tsai, Fuu‐Jen; Chiu, Hong‐Yi; Juan, Yu‐Ning; Lo, Yu‐Hsiang; Chiang, Jo‐Hua (Environmental toxicology, 2022)
Keywords: aggression; Aggressive behaviour; AKT protein; Apoptosis; Caspase; Cell Line, Tumor; Cell Proliferation; Cell viability; Cells; Curcumin; Curcumin - pharmacology; Curcumin - therapeutic use; Cytotoxicity; drug resistance; Drug Resistance, Neoplasm; ecotoxicology; EGFR; Epidermal growth factor; Epidermal growth factor receptors; ErbB Receptors - genetics; ErbB Receptors - metabolism; Extracellular; Extracellular signal-regulated kinase; Gefitinib; Growth factors; Humans; Inhibitor drugs; Inhibitors; Kinases; Melanoma; Melanoma - drug therapy; Melanoma - genetics; Melanoma - pathology; Membrane potential; Mitochondria; mitochondrial membrane; mitogen-activated protein kinase; Mutation; Neoplasms; Proliferation; Protein-serine/threonine kinase; Reactive oxygen species; Serine; Signal Transduction; Signaling; therapeutics; Threonine; Tumors; vemurafenib; Vemurafenib - pharmacology; Vemurafenib - therapeutic use; vemurafenib‐resistant A375.S2 cells; vemurafenib; apoptosis; melanoma; EGFR; vemurafenib-resistant A375.S2 cells