Mycobacterium avium infection of macrophages results in progressive suppression of interleukin-12 production in vitro and in vivo

• Published in: Journal of leukocyte biology Vol. 71; no. 1; pp. 80 - 88
• Main Authors: Wagner, Dirk, Sangari, Felix J., Kim, Sang, Petrofsky, Mary, Bermudez, Luiz E.
• Format: Journal Article
• Language: English
• Published: United States Society for Leukocyte Biology 01.01.2002
• Subjects: Animals; Cells, Cultured; Humans; Interleukin-10 - immunology; Interleukin-12 - biosynthesis; Interleukin-12 - immunology; Listeria monocytogenes; Macrophages - immunology; Macrophages - microbiology; Mice; Mycobacterium avium; Mycobacterium avium - immunology; Transforming Growth Factor beta - immunology; transforming growth factor-^b1; Tuberculosis - immunology

Interleukin‐12 (IL‐12) has been shown to have an important role in thehost defense against Mycobacterium avium. We sought todetermine if human monocyte‐derived macrophages produce IL‐12 uponM. avium infection. Although IL‐12 can be measured insupernatants of M. avium‐infected macrophages at 24, 48,a...