Pharmacokinetic–pharmacodynamic modelling for the determination of optimal dosing regimen of florfenicol in Nile tilapia (Oreochromis niloticus) at different water temperatures and antimicrobial susceptibility levels

• Published in: Journal of fish diseases Vol. 42; no. 8; pp. 1181 - 1190
• Main Authors: Rairat, Tirawat, Hsieh, Chia‐Yu, Thongpiam, Wipavee, Chou, Chi‐Chung
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.08.2019
• Subjects: adverse effects; antibiotic resistance; Antibiotics; Antiinfectives and antibacterials; blood proteins; Dosage; dose response; Drug dosages; Drugs; Fish; Florfenicol; Freshwater fishes; In vivo methods and tests; in vivo studies; Linearity; Marine fishes; Metabolism; Minimum inhibitory concentration; Nile tilapia; optimal dosing regimen; Oral administration; Oreochromis niloticus; Pathogens; Pharmacodynamics; Pharmacokinetics; pharmacokinetic–pharmacodynamic; Pharmacology; Ponds; protein binding; Saturation; Serum; Side effects; Temperature; Temperature dependence; Tilapia; Water temperature; pharmacokinetic-pharmacodynamic; Nile tilapia; florfenicol; optimal dosing regimen

Optimized dosing regimen is key to the effective use of antibacterials and to minimizing drug‐related side effects. The current study established a pharmacokinetic–pharmacodynamic (PK‐PD) model for the determination of optimal antibacterial dosing regimen in fish taken into consideration the tempera...