Pharmacokinetic–pharmacodynamic modelling for the determination of optimal dosing regimen of florfenicol in Nile tilapia (Oreochromis niloticus) at different water temperatures and antimicrobial susceptibility levels - Rairat, Tirawat; Hsieh, Chia‐Yu; Thongpiam, Wipavee; Chou, Chi‐Chung (Journal of fish diseases, 2019)
Keywords: adverse effects; antibiotic resistance; Antibiotics; Antiinfectives and antibacterials; blood proteins; Dosage; dose response; Drug dosages; Drugs; Fish; Florfenicol; Freshwater fishes; In vivo methods and tests; in vivo studies; Linearity; Marine fishes; Metabolism; Minimum inhibitory concentration; Nile tilapia; optimal dosing regimen; Oral administration; Oreochromis niloticus; Pathogens; Pharmacodynamics; Pharmacokinetics; pharmacokinetic–pharmacodynamic; Pharmacology; Ponds; protein binding; Saturation; Serum; Side effects; Temperature; Temperature dependence; Tilapia; Water temperature; pharmacokinetic-pharmacodynamic; Nile tilapia; florfenicol; optimal dosing regimen