Macrophage Infiltrate Is Elevated in CRSwNP Sinonasal Tissue Regardless of Atopic Status

• Published in: Otolaryngology-head and neck surgery Vol. 151; no. 2; p. 215
• Main Authors: Banks, Caroline A, Schlosser, Rodney J, Wang, Eric W, Casey, Sarah E, Mulligan, Ryan M, Mulligan, Jennifer K
• Format: Journal Article
• Language: English
• Published: England 01.08.2014
• Subjects: Adult; Antigens, CD - immunology; Antigens, Differentiation, Myelomonocytic - immunology; Biomarkers - analysis; Case-Control Studies; Female; Humans; Immunohistochemistry; Macrophages - immunology; Male; Middle Aged; Nasal Polyps - immunology; Prospective Studies; Rhinitis - immunology; Sinusitis - immunology; atopy; chronic rhinosinusitis; nasal polyps; macrophage

Macrophages are major producers of inflammatory cytokines; however, their role in chronic rhinosinusitis (CRS) has not been clearly defined. The aim of this study was to quantify macrophages in sinus tissue of patients with various subtypes of CRS and determine the impact of atopic status on macroph...