N‐glycan based models improve diagnostic efficacies in hepatitis B virus‐related hepatocellular carcinoma

• Published in: International journal of cancer Vol. 127; no. 1; pp. 148 - 159
• Main Authors: Fang, Meng, Zhao, Yun‐Peng, Zhou, Fei‐Guo, Lu, Lun‐Gen, Qi, Peng, Wang, Hao, Zhou, Kun, Sun, Shu‐Han, Chen, Cui‐Ying, Gao, Chun‐Fang
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.07.2010; Wiley-Blackwell
• Subjects: Adult; Biological and medical sciences; Carcinoma, Hepatocellular - diagnosis; Carcinoma, Hepatocellular - virology; Female; Gastroenterology. Liver. Pancreas. Abdomen; hepatitis B virus (HBV); Hepatitis B virus - pathogenicity; hepatocellular carcinoma (HCC); Humans; Immunoglobulin G - blood; liver fibrosis; Liver Neoplasms - diagnosis; Liver Neoplasms - virology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; marker; Medical sciences; Models, Theoretical; N‐glycan; Polysaccharides - analysis; Reproducibility of Results; Sensitivity and Specificity; Tumors; Hepatic fibrosis; hepatitis B virus (HBV); Treatment efficiency; Orthohepadnavirus; Biological marker; Hepatic disease; Hepatocellular carcinoma; hepatocellular carcinoma (HCC); Malignant tumor; Glycan; Virus; Liver cancer; liver fibrosis; Cancerology; Hepadnaviridae; marker; Digestive diseases; Models; N-glycan; Diagnosis; Hepatitis B virus; Cancer

The early diagnosis of hepatocellular carcinoma (HCC) is of great clinical desirable due to lack of specific and sensitive markers. Alterations in the sugar chains of glycoprotein synthesized by the liver contribute to the molecular basis of abnormalities in carcinogenesis. This study aims to constr...