MicroRNA-661, a c/EBPα Target, Inhibits Metastatic Tumor Antigen 1 and Regulates Its Functions

• Published in: Cancer research (Chicago, Ill.) Vol. 69; no. 14; pp. 5639 - 5642
• Main Authors: Reddy, Sirigiri Divijendra Natha, Pakala, Suresh B., Ohshiro, Kazufumi, Rayala, Suresh K., Kumar, Rakesh
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.07.2009
• Subjects: Antineoplastic agents; Biological and medical sciences; Medical sciences; Pharmacology. Drug treatments; Tumors; Gene silencing; Target; RNA interference; Tumor associated antigen; Targeting; Micro RNA; Advanced stage; Inhibitor; Malignant tumor; Metastasis; Cancer; C/EBP transcription factor

MicroRNAs (miR) have been identified as posttranscriptional modifiers of target gene regulation and control the expression of gene products important in cancer progression. Here, we show that miR-661 inhibits the expression of metastatic tumor antigen 1 (MTA1), a widely up-regulated gene product in...