Carcinoembryonic Antigen Interacts with TGF-β Receptor and Inhibits TGF-β Signaling in Colorectal Cancers

• Published in: Cancer research (Chicago, Ill.) Vol. 70; no. 20; pp. 8159 - 8168
• Main Authors: Li, Ying, Cao, Hong, Jiao, Zhongxian, Pakala, Suresh B., Sirigiri, Divijendra Natha Reddy, Li, Wenpin, Kumar, Rakesh, Mishra, Lopa
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.10.2010
• Subjects: Antineoplastic agents; Biological and medical sciences; Gastroenterology. Liver. Pancreas. Abdomen; Medical sciences; Pharmacology. Drug treatments; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; Rectal disease; Tumor associated antigen; Oncofetal antigen; Transforming growth factor β; Colorectal cancer; Tumoral marker; Malignant tumor; Colonic disease; Carcinoembryonic antigen; Signal transduction; Digestive diseases; Intestinal disease; Inhibitor; Cancer; Biological receptor

As a tumor marker for colorectal cancers, carcinoembryonic antigen (CEA) enhances the metastatic potential of cancer cells. CEA functions as an intercellular adhesion molecule and is upregulated in a wide variety of human cancers. However, the molecular mechanisms by which CEA mediates metastasis re...