A new liposomal liver-specific contrast agent for CT: first human phase-I clinical trial assessing efficacy and safety

• Published in: European radiology Vol. 11; no. 4; pp. 698 - 704
• Main Authors: Leander, P, Höglund, P, Børseth, A, Kloster, Y, Berg, A
• Format: Journal Article
• Language: English
• Published: Germany Springer Nature B.V 01.01.2001
• Subjects: Adult; Chromatography, High Pressure Liquid; Clinical Medicine; Clinical trials; Contrast media; Contrast Media - pharmacokinetics; Female; Humans; Klinisk medicin; Liposome encapsulated; Liposomes - administration & dosage; Liver; Liver - diagnostic imaging; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Radiologi och bildbehandling; Radiology, Nuclear Medicine and Medical Imaging; Tissue Distribution; Tomography, X-Ray Computed; Triiodobenzoic Acids - pharmacokinetics

In this first clinical trial liposome-encapsulated iodixanol, CT particles (CTP) were studied. The aims of the present trial were to assess the efficacy of CTP in CT and to determine the safety of different doses of CTP. A total of 47 healthy volunteers were enrolled in the present study. The CTP wa...