The effect of the mtDNA4834 deletion on hearing

• Published in: Biochemical and biophysical research communications Vol. 344; no. 1; pp. 425 - 430
• Main Authors: Kong, Wei-Jia, Hu, Yu-Juan, Wang, Qiong, Wang, Ying, Han, Yue-Chen, Cheng, Hua-Mao, Kong, Wen, Guan, Min-Xin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.05.2006
• Subjects: Aging - genetics; Aminoglycoside antibiotic; Aminoglycosides - toxicity; Animals; Anti-Bacterial Agents - toxicity; Auditory Threshold; Common deletion; d-Galactose; Disease Models, Animal; DNA, Mitochondrial - drug effects; DNA, Mitochondrial - genetics; Ear, Inner - drug effects; Ear, Inner - enzymology; Galactose - toxicity; Genetic Predisposition to Disease; Hearing Loss - genetics; Malondialdehyde - analysis; Malondialdehyde - metabolism; Mitochondrial DNA; Presbyacusis; Rats - genetics; Rats, Wistar; Sequence Deletion; Stress; Superoxide Dismutase - analysis; Superoxide Dismutase - metabolism; Presbyacusis; Mitochondrial DNA; Aminoglycoside antibiotic; d-Galactose; Common deletion; Stress

Mutations in mitochondrial DNA (mtDNA) are associated with diverse pathological states in humans, notably sensorineural deafness. In humans, mtDNA4977 deletion, known as common deletion, is thought to play a critical role in presbyacusis. A similar mtDNA deletion occurs in the naturally aging rats i...