Endoplasmic Reticulum Stress and Unfolded Protein Response in Vernal Keratoconjunctivitis

• Published in: Investigative ophthalmology & visual science Vol. 65; no. 4; p. 23
• Main Authors: Leonardi, Andrea, Donato, Alice, Rosani, Umberto, Di Stefano, Antonino, Cavarzeran, Fabiano, Brun, Paola
• Format: Journal Article
• Language: English
• Published: United States The Association for Research in Vision and Ophthalmology 01.04.2024
• Subjects: Conjunctiva; Conjunctivitis, Allergic - genetics; Cornea; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress - genetics; Humans; Inflammation; Quality of Life; Unfolded Protein Response

Vernal keratoconjunctivitis (VKC) is an ocular allergic disease characterized by a type 2 inflammation, tissue remodeling, and low quality of life for the affected patients. We investigated the involvement of endoplasmic reticulum (ER) stress and unfolded protein response in VKC. Conjunctival imprin...