Proteasome modulating agents induce rAAV2-mediated transgene expression in human intestinal epithelial cells

• Published in: Biochemical and biophysical research communications Vol. 331; no. 4; pp. 1392 - 1400
• Main Authors: Tang, Shiue-Cheng, Sambanis, Athanassios, Sibley, Eric
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 17.06.2005
• Subjects: Adeno-associated virus; Adriamycin; Caco-2 Cells; Cysteine Proteinase Inhibitors - pharmacology; Dependovirus - genetics; Doxorubicin; Doxorubicin - pharmacology; Enterocytes; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Humans; Intestinal gene transfer; Intestinal Mucosa - drug effects; Intestinal Mucosa - metabolism; MG101; Oligopeptides - pharmacology; Proteasome Endopeptidase Complex - drug effects; Short bowel syndrome; Transduction, Genetic; Transgenes; Enterocytes; Intestinal gene transfer; Short bowel syndrome; Doxorubicin; Adriamycin; MG101

Intestinal gene transfer offers promise as a therapeutic option for treatment of both intestinal and non-intestinal diseases. Recombinant adeno-associated virus serotype 2, rAAV2, based vectors have been utilized to transduce lung epithelial cells in culture and in human subjects. rAAV2 transduction...