Single-cell landscape of alternative polyadenylation in human lymphoid hematopoiesis

• Published in: Journal of molecular cell biology Vol. 16; no. 7
• Main Authors: Qiang, Jiaqi, Yu, Shan, Li, Jun, Rong, Yu, Wang, Xiaoshuang, Zhu, Yong, Wang, Fang
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 20.12.2024
• Subjects: 3' Untranslated Regions - genetics; Cell Differentiation - genetics; Hematopoiesis - genetics; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - metabolism; Humans; Lymphocytes - cytology; Lymphocytes - metabolism; Polyadenylation - genetics; Single-Cell Analysis - methods; Transcriptome - genetics; lymphoid differentiation; single-cell; hematopoiesis; post-transcription; alternative polyadenylation
• ISSN: 1674-2788; 1759-4685; 1759-4685
• DOI: 10.1093/jmcb/mjae027

Alternative polyadenylation (APA) is an essential post-transcriptional process that produces mature mRNA isoforms by regulating the usage of polyadenylation sites (PASs). APA is involved in lymphocyte activation; however, its role throughout the entire differentiation trajectory remains elusive. Her...