Local delivery of E2F decoy oligodeoxynucleotides using ultrasound with microbubble agent (Optison) inhibits intimal hyperplasia after balloon injury in rat carotid artery model

• Published in: Biochemical and biophysical research communications Vol. 317; no. 2; pp. 508 - 514
• Main Authors: Hashiya, Naotaka, Aoki, Motokuni, Tachibana, Katsuro, Taniyama, Yoshiaki, Yamasaki, Keita, Hiraoka, Kazuya, Makino, Hirofumi, Yasufumi, Kaneda, Ogihara, Toshio, Morishita, Ryuichi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 30.04.2004
• Subjects: Angioplasty, Balloon, Coronary - adverse effects; Animals; Blood vessel; Carotid Arteries - pathology; Cell Cycle Proteins; Coronary Restenosis - etiology; Coronary Restenosis - genetics; Coronary Restenosis - pathology; Coronary Restenosis - therapy; Decoy; DNA-Binding Proteins; E2F; E2F Transcription Factors; Echo-contrast microbubble agent; Feasibility Studies; Genetic Therapy - methods; Male; Microbubbles; Oligodeoxyribonucleotides - administration & dosage; Oligodeoxyribonucleotides - therapeutic use; Optison; Rats; Rats, Sprague-Dawley; Restenosis; Transcription Factors - genetics; Transcription Factors - metabolism; Transfection - methods; Treatment Outcome; Ultrasonic Therapy - methods; Ultrasound; Restenosis; Decoy; Optison; Blood vessel; E2F; Echo-contrast microbubble agent; Ultrasound

Since restenosis after angioplasty still remains a major clinical problems, inhibition of neointimal formation is an important subject. In this study, we focused on the transcription factor, E2F, that plays a pivotal role in the transactivation of cell-cycle regulatory genes, and also we developed a...