Structural and Functional Effects of C5aR1 Antagonism in a Rat Model of Neonatal Hypoxic-Ischemic Encephalopathy

• Published in: Developmental neuroscience Vol. 47; no. 2; pp. 112 - 126
• Main Authors: Saadat, Angela, Pallera, Haree, Lattanzio, Frank, Owens, Daley, Gaines, Amy, Ravi, Sai Susmitha, Shah, Tushar
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland 01.04.2025
• Subjects: Animals; Animals, Newborn; Disease Models, Animal; Female; Hypoxia-Ischemia, Brain - drug therapy; Hypoxia-Ischemia, Brain - metabolism; Hypoxia-Ischemia, Brain - pathology; Hypoxia-Ischemia, Brain - physiopathology; Male; Motor Activity - drug effects; Neuroprotective Agents - pharmacology; Rats; Rats, Sprague-Dawley; Receptor, Anaphylatoxin C5a - antagonists & inhibitors; Receptor, Anaphylatoxin C5a - metabolism; Research Article; Animal model; Complement; Inflammation; Hypoxia-ischemia; Reperfusion injury; Neonatal brain injury

Abstract Introduction: The complement response activates upon reperfusion in neonatal hypoxic-ischemic encephalopathy (HIE) and contributes to excessive neuroinflammation and worse outcomes. C5a is a powerful anaphylatoxin central to each of the complement pathways, and its engagement with C5aR1 is...