Large-scale analyses of synonymous substitution rates can be sensitive to assumptions about the process of mutation

• Published in: Gene Vol. 378; pp. 58 - 64
• Main Authors: Aris-Brosou, Stéphane, Bielawski, Joseph P.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.08.2006
• Subjects: Amino Acid Substitution; Animals; Bacteria; Codon - genetics; Codon model; Computer Simulation; Databases, Genetic; Drosophila; Evolution, Molecular; Genome; Models, Genetic; Mutation; Natural selection; Rodents; Selection, Genetic; Synonymous rate; Time Factors; GY; Synonymous rate; Drosophila; Rodents; NG; Bacteria; CAI; MG; ENC; Codon model; Natural selection

A popular approach to examine the roles of mutation and selection in the evolution of genomes has been to consider the relationship between codon bias and synonymous rates of molecular evolution. A significant relationship between these two quantities is taken to indicate the action of weak selectio...