Effects of cytotoxic nucleus accumbens lesions on instrumental conditioning in rats

• Published in: Experimental brain research Vol. 144; no. 1; pp. 50 - 68
• Main Authors: de Borchgrave, R., Rawlins, J. N. P., Dickinson, A., Balleine, B. W.
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.05.2002; Springer Nature B.V
• Subjects: Amphetamines; Anatomical correlates of behavior; Animals; Appetitive Behavior - drug effects; Appetitive Behavior - physiology; Arousal - drug effects; Arousal - physiology; Behavioral psychophysiology; Biological and medical sciences; Conditioning (Psychology) - drug effects; Conditioning (Psychology) - physiology; Cytotoxicity; Denervation; Dextroamphetamine - pharmacology; Experimental psychology; Extinction; Extinction, Psychological - drug effects; Extinction, Psychological - physiology; Feeding Behavior - drug effects; Feeding Behavior - physiology; Fundamental and applied biological sciences. Psychology; Male; Motivation; Neural Pathways - drug effects; Neural Pathways - pathology; Neural Pathways - physiopathology; Neurons - drug effects; Neurons - pathology; Neurotoxins - pharmacology; Nucleus Accumbens - drug effects; Nucleus Accumbens - pathology; Nucleus Accumbens - physiopathology; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Rats, Inbred Strains; Reinforcement (Psychology); Sympathomimetics - pharmacology; Los Angeles California; United States > US; Rat; Rodentia; Central nervous system; Instrumental conditioning; Basal ganglion; Learning; Nucleus accumbens; Vertebrata; Mammalia; Acquisition process; Animal; Reinforcement; Amfetamine; Brain (vertebrata)

In two experiments the involvement of the nucleus accumbens in instrumental conditioning was investigated using rats as subjects. In experiment 1, extensive bilateral cytotoxic lesions of the nucleus accumbens mildly suppressed instrumental responding reinforced with food, but had no detectable effe...