Collagen Autoantibodies and Their Relationship to CCP Antibodies and Rheumatoid Factor in the Progression of Early Rheumatoid Arthritis

• Published in: Antibodies (Basel) Vol. 6; no. 2; p. 6
• Main Authors: Whittingham, Senga, Stockman, Alex, Rowley, Merrill
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 05.04.2017; MDPI
• Subjects: anti-citrullinated protein antibodies; Arthritis; Autoantibodies; Autoantigens; Cartilage; Citrulline; Collagen; Collagen (type II); collagen antibodies; Damage localization; Enzyme-linked immunosorbent assay; Health risk assessment; immune complexes; Immunoglobulins; Monoclonal antibodies; Peptides; Proteins; Remission; Rheumatoid arthritis; Rheumatoid factor

Serum autoantibodies to cyclic citrullinated peptides (anti-CCP) and rheumatoid factor (RF) are important markers for diagnosis and prognosis of rheumatoid arthritis (RA), but their autoantigens are not cartilage-specific. Autoantibodies to joint-specific type II collagen (CII) also occur in RA, and...