Genetic analysis of Caveolin-1 and eNOS genes in colorectal cancer

• Published in: Oncology reports Vol. 16; no. 2; pp. 353 - 359
• Main Authors: CONDE, Manuel Chaves, RAMIREZ-LORCA, Reposo, ROYO, Jose Luis, LOPEZ-JAMAR, Jose Miguel Esteban, MOLERO, Eva, RAMIREZ-ARMENGOL, Juan Andres, NOGUEIRA, Jose Andres Moreno, PASCUAL, Manuel Hidalgo, RUIZ, Agustin, MARTIN-CORDOVA, Carlos Garcia, REAL, Luis Miguel
• Format: Journal Article
• Language: English
• Published: Athens S.n. 01.08.2006
• Subjects: Aged; Alleles; Biological and medical sciences; Caveolin 1 - genetics; Colorectal Neoplasms - genetics; Female; Gastroenterology. Liver. Pancreas. Abdomen; Genetic Predisposition to Disease; Haplotypes; Humans; Male; Medical sciences; Middle Aged; Nitric Oxide Synthase Type III - genetics; Polymorphism, Single Nucleotide; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; Caveolin-1; eNOS; Rectal disease; Colorectal cancer; pyrosequencing; Malignant tumor; Colonic disease; Cancerology; Caveolin 1; Digestive diseases; Intestinal disease; Genetics; Heritability
• ISSN: 1021-335X; 1791-2431
• DOI: 10.3892/or.16.2.353

Caveolae are involved in physical compartmentalization between different groups of signaling events. Its main component, CAV1, modulates different pathways in cellular physiology. The emerging evidence pointing to the role of CAV1 in cancer led us to study whether different alleles of this gene are associated with colorectal cancer (CRC). Since one of the most characterized enzymes regulated by CAV1 is eNOS, we decided to include both genes in this study. We analyzed five SNPs in 360 unrelated CRC patients and 550 controls from the general population. Two of these SNPs were located within eNOS and three within the CAV1 gene. Although haplotype distribution was not associated with CRC, haplotype TiA (CAV1) was associated with familiar forms of CRC (p<0.05). This was especially evident in CRC antecedents and nuclear forms of CRC. If both CG (eNOS) and TiA (CAV1) haplotypes were taken together, this association increased in significance. Thus, we propose that CAV1, either alone or together with eNOS alleles, might modify CRC heritability.