The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice - Paterson, Neil E.; Semenova, Svetlana; Gasparini, Fabrizio; Markou, Athina (Psychopharmacologia, 2003)
Keywords: Animals; Behavior, Animal - drug effects; Biological and medical sciences; Dose-Response Relationship, Drug; Drug Administration Routes - veterinary; Drug Administration Schedule - veterinary; Drug Interactions; Excitatory Amino Acid Antagonists - pharmacology; Feeding Behavior - drug effects; Male; Medical sciences; Mice; Mice, Inbred DBA; Nicotine - administration & dosage; Nicotinic Agonists - administration & dosage; Pyridines - pharmacology; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate - antagonists & inhibitors; Receptors, Metabotropic Glutamate - physiology; Reinforcement Schedule; Self Administration - methods; Self Administration - veterinary; Tobacco, tobacco smoking; Toxicology; Intraperitoneal administration; Intravenous administration; Rat; Self administration; Dose activity relation; Learning; Alkaloid; Acquisition process; Dependence; Reinforcement; Antagonist; Mechanism of action; Self-administration; mglu5 glutamate receptor; Poison withdrawal; Rodentia; Rats; Instrumental conditioning; MPEP; Biological activity; Vertebrata; Mammalia; Mouse; Animal; Mice; mGluR5; Nicotine