Inflammatory and tolerogenic myeloid cells determine outcome following human allergen challenge

• Published in: The Journal of experimental medicine Vol. 220; no. 9
• Main Authors: Voskamp, Astrid L., Tak, Tamar, Gerdes, Maarten L., Menafra, Roberta, Duijster, Ellen, Jochems, Simon P., Kielbasa, Szymon M., Kormelink, Tom Groot, Stam, Koen A., van Hengel, Oscar R.J., de Jong, Nicolette W., Hendriks, Rudi W., Kloet, Susan L., Yazdanbakhsh, Maria, de Jong, Esther C., Gerth van Wijk, Roy, Smits, Hermelijn H.
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 04.09.2023
• Subjects: Allergens; Humans; Inflammation - pathology; Innate Immunity and Inflammation; Mucosal Immunology; Myeloid Cells - pathology; Nasal Mucosa; Rhinitis, Allergic, Perennial - pathology

Innate mononuclear phagocytic system (MPS) cells preserve mucosal immune homeostasis. We investigated their role at nasal mucosa following allergen challenge with house dust mite. We combined single-cell proteome and transcriptome profiling on nasal immune cells from nasal biopsies cells from 30 all...